Julio Licinio

Julio Licinio
Julio Licinio
Born Belo Horizonte, Minas Gerais, Brazil
Residence Adelaide
Nationality American, Australian, Brazilian
Fields Psychiatry
Institutions Yale University, NIH Intramural Research Program, UCLA, University of Miami Miller School of Medicine, John Curtin School of Medical Research, Flinders University
Alma mater Federal University of Bahia
Known for Pharmacogenomics, biology of depression
Spouse Ma-Li Wong
Website
www.flinders.edu.au/people/julio.licinio

Julio Licinio is deputy director (Translation Strategy and Process) at the South Australian Health and Medical Research Institute[1] where he heads the Mind & Brain Theme. He is also Matthew Flinders Distinguished Professor of Psychiatry at Flinders University in Adelaide,[2][3] clinical professor of psychiatry at the University of New Mexico School of Medicine in Albuquerque, adjunct professor of psychiatry at the UT (University of Texas) Health Science Center at Houston, and visiting professor of psychiatry, University of Minho in Braga. He is the former director of the John Curtin School of Medical Research, Australian National University (from 2009 to 2013), where he founded the John Curtin Medical Research Foundation.[4] Licinio is the founding and current chief editor of three journals from the Nature Publishing Group, namely Molecular Psychiatry,[5] Translational Psychiatry,[6] and The Pharmacogenomics Journal.[7]

His area of scientific expertise is pharmacogenomics,[8] as well as the biology of depression, and he has edited books on both topics.[9][10] He has also published considerable research on translational psychiatry, as well as on obesity and the possible link between obesity, depression, and antidepressants.[11][12][13]

Education

Licinio lived in the United States for 25 years (1984–2009), but originally received his MD from the Federal University of Bahia in 1982, and completed his residency in internal medicine at the University of São Paulo from 1982 to 1984. He then moved to the United States and completed training in endocrinology at The University of Chicago, and psychiatry at Albert Einstein in the Bronx as well as at Weill Cornell Medical College. Licinio is registered as a specialist in psychiatry by the Australian Health Practitioner Regulation Agency.[14] He is board certified in psychiatry by the American Board of Psychiatry and Neurology and he is a Fellow of the Royal Australian and New Zealand College of Psychiatrists, the American Psychiatric Association, and the American College of Neuropsychopharmacology.

Career

Licinio was previously an assistant professor of psychiatry at Yale University, then he was a Unit Chief within the Clinical Neurodocrinology Branch of the National Institute of Mental Health NIH Intramural Research Program (1993–1999), and later was professor of psychiatry and medicine/endocrinology at the David Geffen School of Medicine at UCLA from 1999 until 2006, where he had multiple roles, such as Founding Director of three NIH funded programs: the Interdepartmental Center on Clinical Pharmacology, the Graduate Training in Translational and Clinical Investigation and the Mentored Clinical Pharmacology Scholars Program; he also co-directed (with Ma-Li Wong) the UCLA Center for Pharmacogenomics, was Associate Program Director of the UCLA General Clinical Research Center, and Vice-Chair of Psychiatry & Biobehavioral Sciences.[2] In 2006 he was appointed the Miller Professor of Psychiatry, Chairman of Psychiatry & Behavioral Sciences and subsequently Associate Dean for project development, responsible for starting the Clinical and Translational Science Institute at the University of Miami Miller School of Medicine, where he worked until 2009,[15] when he moved to Australia as Director of the John Curtin School of Medical Research.

During the period 1993–2001, Licinio was a Temporary Advisor to the World Health Organization (WHO), having co-chaired ten WHO scientific meetings in seven countries, and co-edited the resulting ten books containing the proceedings of those meetings, mostly focused on the role of dysthymia in neurological disorders.[16][17][18][19][20][21][22]

In 2005–2010, Licinio was a member of the United States Secretary of Health and Human Services Advisory Committee of Genetics Health and Society (SACGHS).[23] The key issue addressed during his term was the Genetic Information Nondiscrimination Act (GINA), which was strongly supported by the SACGHS. GINA was enacted on 21 May 2008 (Pub.L. 110–233, 122 Stat. 881)[24] as an Act of Congress in the United States, designed to prohibit the use of genetic information in health insurance and employment. The Act prohibits group health plans and health insurers from denying coverage to a healthy individual or charging that person higher premiums based solely on a genetic predisposition to developing a disease in the future. The legislation also bars employers from using individuals' genetic information when making hiring, firing, job placement, or promotion decisions.[25] Senator Ted Kennedy called it the "first major new civil rights bill of the new century."[26] The Act contains amendments to the Employee Retirement Income Security Act of 1974[27] and the Internal Revenue Code of 1986.[28]

Licinio's work has broad international recognition. He has advised on more than 90 review panels and committees, had over 200 abstracts at meeting presentations, and organised more than 60 symposia, conferences and workshops. He is the head of the Australian node of the German-Australian Institute for Translational Medicine (GAITM), directed by Stefan R. Bornstein.[29] In 2013 he gave the opening Presidential Lecture at the European Congress of Psychiatry, Nice, France, the Eliahu Youdim Memorial Lecture at National Institute for Psychobiology in Jerusalem, Israel, the Kester Brown (opening) Lecture at the Australian Society of Anaesthesiology Annual Meeting in Canberra, the Roche Oration, Australasian Society of Psychiatric Research in Melbourne, the Opening Plenary Lecture at the Bio21 Cluster and Museum Victoria Conference: Biological Markers for Mental Health. He delivered the opening keynote lecture of the German 2014 Conference “Biomarkers & Biologically guided options of Child Psychiatric Disorders” in Frankfurt, and was appointed Visiting Professor of Psychiatry at Paris Descartes University (Université Paris 5 René Descartes, also known as Paris V) (2012-2014) and University of Minho, Braga, Portugal, competitively funded by the governments of France and Portugal. He was invited to give a Distinguished Psychiatrist lecture at the meeting of the American Psychiatric Association (APA) of which he is a member (past co-chair) of the Scientific Program Committee. In the last 5 years he published collaboratively with 190 colleagues from 54 institutions, located in 19 countries, including Nobel Laureates Andrew Schally[30] and Rita Levi-Montalcini.[31] He is a current reviewer for the large translational centre programs funded by the governments of the UK (Biomedical Research Centres and Units, NIHR), Canada (Support for People and Patient-Oriented Research and Trials – SUPPORT – Units, Canadian Institutes of Health Research), and Switzerland (National Centers for Competence in Research, Swiss National Science Foundation).

Scientific research

According to Google Scholar, Licinio has an h-index of 65, with over 21,000 citations.[32] He has published over 240 papers indexed in Pubmed,[33] as well as 12 books.

Licinio is known for his research into leptin and its role in conveying a feeling of satiety. For example, in 2002, he identified three people from Turkey who suffered from a genetic disorder called leptin deficiency – the only three adults known at that time to have this disorder – all of whom were severely overweight as a result.[34] He then administered daily leptin injections to each of them, and found that after ten months, the patients had lost half of his or her original body weight.[35][36] He discovered that despite being produced by a dispersed mass of fat cells, leptin is secreted in a highly organised manner with distinct pulsatility and circadian rhythm and that it appears to regulate the minute-to-minute rhythms of several endocrine axes, such as the hypothalamic-pituitary-adrenal axis, the hypothalamic–pituitary–thyroid axis, and the hypothalamic–pituitary–gonadal axis.[37][38][39] Licinio and his colleagues were the first to suggest that leptin may have antidepressant effects,[40] a concept that was subsequently extended by other groups.[41][42] He also contributed to pioneer the concept that leptin has pro-cognitive effects in humans.[43]

With his group, Licinio conducted an extensive body of work on the pharmacogenomics of depression that started in 2000 as part of the National Institute of General Medical Sciences NIH Pharmacogenomics Research Network (PGRN).[44] In that project, he and his team studied a Mexican-American population with major depressive disorder in the city of Los Angeles, in the context of an extensive process of community engagement,[45] which received Certificates of Commendation both from the California State Legislature and the United States Congress. He contributed the Mexican-American samples to the International HapMap Project.[46] His pharmacogenetics research has resulted in several publications on predictors of antidepressant treatment response in this population.[47][48][49][50][51]

Wong and Licinio contributed some of the earliest work on the role of cytokines and immune mediators in the brain, with implications for the underlying biology of major depressive disorder,[52] and published scientific articles on the localisation of gene expression for interleukin 1 receptor antagonist,[53] interleukin 1 receptor, type I (IL1R1), also known as CD121a (C lustre of D ifferentiation 121a),[54] and inducible nitric oxide synthase (iNOS)[55] in mammalian brain. They also showed that interleukin 1 receptor antagonist is an endogenous neuroprotective agent.[56] They have shown that the central and peripheral cytokine compartments are integrated but differentially regulated.[57] In collaboration with colleagues at Columbia University Licinio and his team showed that inflammation-mediated up-regulation of secretory sphingomyelin phosphodiesterase in vivo represents a possible link between inflammatory cytokines and atherogenesis.[58] Licinio's line of research examining the effects of peripheral inflammation in brain, behaviour and metabolism is ongoing in their lab.[59]

Teaching

Licinio conceptualised, obtained funding for, and directed three graduate training programs with master's degrees in translational investigation, for physician-scientists, at UCLA (supported by an NIH K30 award),[60] University of Miami (supported by an NIH K30 award), and Australian National University. He also created and obtained NIH T32,[61] NIH K12,[62] and PhRMA Foundation (2004 Center of Excellence in Clinical Pharmacology) funding for the UCLA Interdepartmental Clinical Pharmacology Training Program, of which he was founding director (1999–2006).[63] Licinio was the recipient of an NIH K24 award[64] to mentor early career physician-scientists (2002–2007).

Public engagement

Licinio is often asked to comment on items related to his field and more broadly to medical research, science, and academic career development in general.[65][66][67] He wrote four book reviews for Science, including a commentary on the current diagnostic system in psychiatry, the American Psychiatry Association (APA)'s "Diagnostic and Statistical Manual of Mental Disorders", Fifth Edition (DSM-5) and the controversial exhibit on Sigmund Freud at the US Library of Congress.[68][69][70][71] Licinio writes a popular blog on science-related matters for the general public.[72]

Personal life

Licinio's wife, Ma-Li Wong is also an expert on depression, pharmacogenomics and psychoneuroimmunology; they have worked together for over 20 years, and have co-authored over 150 papers,[73][74] and co-edited two multi-authored books on pharmacogenomics[75] and the biology of depression.[76] Wong and Licinio have two adult children.

References

  1. ↑ "Management: Professor Julio Licinio". South Australian Health and Medical Research Institute. Retrieved 25 November 2015.
  2. 1 2 "Professor Julio Licinio". Flinders University. Retrieved 25 November 2015.
  3. ↑ "http://jcsmr.anu.edu.au/News-events/21mar2013/congratulations-professor-julio-licinio". John Curtin School of Medical Research. 21 March 2013. Retrieved 15 October 2014. External link in |title= (help)
  4. ↑ "The John Curtin Medical Research Foundation". Australia National University. Retrieved 15 October 2014.
  5. ↑ "Molecular Psychiatry". Nature Publishing Group. 12 October 2014. Retrieved 12 October 2014.
  6. ↑ "Translational Psychiatry". Nature Publishing Group. 12 October 2014. Retrieved 12 October 2014.
  7. ↑ "The Pharmacogenomics Journal". Nature Publishing Group. 12 October 2014. Retrieved 12 October 2014.
  8. ↑ "Professor Julio Licinio: The pharmacogenomics of depression at ANU". Australia National University. 19 September 2010. Retrieved 15 October 2014.
  9. ↑ "Pharmacogenomics: The Search for Individualized Therapies". Wiley Online Library. 12 October 2014. Retrieved 12 October 2014.
  10. ↑ "Biology of Depression: From Novel Insights to Therapeutic Strategies". Wiley Online Library. 12 October 2014. Retrieved 12 October 2014.
  11. ↑ Garrett, Catherine (31 May 2010). "Stateline lunches with Professor Julio Licinio, the new head of the John Curtin School of Medical Research". ABC News (Australia). Retrieved 15 October 2014.
  12. ↑ Metherell, Mark (14 May 2011). "A bitter pill: from depression to obesity". Sydney Morning Herald. Retrieved 28 January 2014.
  13. ↑ Mastronardi, C.; Paz-Filho, G. J.; Valdez, E.; Maestre-Mesa, J.; Licinio, J.; Wong, M. L. (March 2011). "Long-term body weight outcomes of antidepressant-environment interactions". Molecular Psychiatry. 16 (3): 265–272. doi:10.1038/mp.2010.122.
  14. ↑ "Australian Health Practitioner Regulation Agency". 13 October 2014. Retrieved 13 October 2014.
  15. ↑ "Julio Licinio". The Conversation. 28 April 2011. Retrieved 29 October 2013.
  16. ↑ "Dysthymia in neurological disorders : proceedings of WHO meeting. Editors: J. Licinio, L. Prilipko, C. L. Bolis". World Health Organization. 1997.
  17. ↑ "Dysthymia : from clinical neuroscience to treatment. Editors: J. Licinio, L. C. L. Bolis, P. Gold". World Health Organization. 1997.
  18. ↑ "Stress and the nervous system. Edited by C. L. Bolis and J. Licinio". World Health Organization. 1998.
  19. ↑ "Genes, behaviour and health. Edited by C. L. Bolis and J. Licinio". World Health Organization. 1999.
  20. ↑ "Stress and adaptation : from Selye's concept to application of modern formulations. Edited by C. L. Bolis and J. Licinio". World Health Organization. 1999.
  21. ↑ "The autonomic nervous system. Edited by C. L. Bolis and J. Licinio". World Health Organization. 1999.
  22. ↑ "Public health aspects of dysthymia in the field of neuroscience. Edited by C. L. Bolis and J. Licinio". World Health Organization. 2000.
  23. ↑ "Secretary's Advisory Committee on Genetics, Health, and Society". NIH. 13 October 2014. Retrieved 13 October 2014.
  24. ↑ "Genetic Information Non-discrimination Act of 2008". United States Government Printing Office. 13 October 2014. Retrieved 13 October 2014.
  25. ↑ "H.R. 493 – Genetic Information Nondiscrimination Act of 2007" (PDF). Office of Management and Budget. 25 April 2007. Retrieved 12 October 2014.
  26. ↑ "Senator Ted Kennedy in Support of Genetic Information Nondiscrimination Bill". 24 April 2008. Retrieved 13 October 2014.
  27. ↑ See Act sec. 101. "Genetic Information Non- discrimination Act of 2008".
  28. ↑ See Act sec. 103. "Genetic Information Non- discrimination Act of 2008".
  29. ↑ "German-Australian Institute for Translational Medicine (GAITM)". Dresden University of Technology. 13 October 2014. Retrieved 13 October 2014.
  30. ↑ Schmid, J.; Ludwig, B.; Schally, A. V.; Steffen, A.; Ziegler, C. G.; Block, N. L.; Koutmani, Y.; Brendel, M. D.; Karalis, K. P.; Simeonovic, C. J.; Licinio, J.; Ehrhart-Bornstein, M.; Bornstein, S. R. (16 August 2011). "Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11beta-hydroxysteroid dehydrogenase". Proceedings of the National Academy of Sciences of the United States of America. 108 (33): 13722–13727. doi:10.1073/pnas.1110965108.
  31. ↑ Bornstein, S. R.; Ehrhart-Bornstein, M.; Androutsellis-Theotokis, A.; Eisenhofer, G.; Vukicevic, V.; Licinio, J.; Wong, M.-L.; Calissano, P.; Nisticò, G.; Preziosi, P.; Levi-Montalcini, R. (April 2012). "Chromaffin cells: the peripheral brain". Molecular Psychiatry. 17 (4): 354–358. doi:10.1038/mp.2011.176.
  32. ↑ "Julio Licinio". Google Scholar. Retrieved 15 October 2014.
  33. ↑ "Pubmed-indexed articles by J Licinio". Pubmed. 13 October 2014. Retrieved 13 October 2014.
  34. ↑ "The Role of Leptin in Weight Loss". ABC News. 7 August 2002. Retrieved 25 March 2014.
  35. ↑ Licinio, J.; Caglayan, S.; Ozata, M.; Yildiz, B. O.; de Miranda, P. B.; O'Kirwan, F.; Whitby, R.; Liang, L.; Cohen, P.; Bhasin, S.; Krauss, R. M.; Veldhuis, J. D.; Wagner, A. J.; DePaoli, A. M.; McCann, S. M.; Wong, M.-L. (9 March 2004). "Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults". Proceedings of the National Academy of Sciences of the United States of America. 101 (13): 4531–4536. doi:10.1073/pnas.0308767101.
  36. ↑ Woznicki, Katrina (24 July 2002). "Leptin helps Turkish family lose weight". UPI. Retrieved 25 March 2014.
  37. ↑ Licinio, J.; Mantzoros, C.; Negrão, A. B.; Cizza, G.; Wong, M.-L.; Bongiorno, P. B.; Chrousos, G. P.; Karp, B.; Allen, C.; Flier, J. S.; Gold, P. W. (May 1997). "Human leptin levels are pulsatile and inversely related to pituitary-adrenal function". Nature Medicine. 3 (5): 575–579. doi:10.1038/nm0597-575. PMID 9142131.
  38. ↑ Licinio, J.; Negrão, A. B.; Mantzoros, C.; Kaklamani, V.; Wong, M.-L.; Bongiorno, P. B.; Mulla, A.; Cearnal, L.; Veldhuis, J. D.; Flier, J. S.; McCann, S. M.; Gold, P. W. (3 March 1998). "Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women". Proceedings of the National Academy of Sciences of the United States of America. 95 (5): 2541–2546. doi:10.1073/pnas.95.5.2541. PMID 9482922.
  39. ↑ Mantzoros, C. S.; Ozata, M.; Negrao, A. B.; Suchard, M. A.; Ziotopoulou, M.; Caglayan, S.; Elashoff, R. M.; Cogswell, R. J.; Negro, P.; Liberty, V.; Wong, M.-L.; Veldhuis, J.; Ozdemir, I. C.; Gold, P. W.; Flier, J. S.; Licinio, J. (July 2001). "Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans". Journal of Clinical Endocrinology and Metabolism. 86 (7): 3284–3291. doi:10.1210/jcem.86.7.7644. PMID 11443202.
  40. ↑ "Methods of neuroendocrine regulation of affective disorders". United States Patent and Trademark Office. 20 January 1998. Retrieved 12 October 2014.
  41. ↑ Lu, X.-Y.; Kim, C. S.; Frazer, A.; Zhang, W. (31 January 2006). "Leptin: a potential novel antidepressant". Proceedings of the National Academy of Sciences of the United States of America. 103 (5): 1593–1598. doi:10.1073/pnas.0508901103. PMID 16423896.
  42. ↑ Hirano, S.; Miyata, S.; Kamei, J. (January 2007). "Antidepressant-like effect of leptin in streptozotocin-induced diabetic mice". Pharmacology Biochemistry and Behavior. 86 (1): 27–31. doi:10.1016/j.pbb.2006.12.003. PMID 17258301.
  43. ↑ Paz-Filho, G. J.; Babikian, T.; Asarnow, R.; Delibasi, T.; Esposito, K.; Erol, H. K.; Wong, M.-L.; Licinio, J. (29 August 2008). "Leptin replacement improves cognitive development". PLOS ONE. 3 (8): e3098. doi:10.1371/journal.pone.0003098.
  44. ↑ "NIH Pharmacogenomics Research Network (PGRN)". NIH. 13 October 2014. Retrieved 13 October 2014.
  45. ↑ International HapMap Consortium (June 2004). "Integrating ethics and science in the International HapMap Project". Nature Reviews Genetics. 5 (6): 467–475. doi:10.1038/nrg1351. PMC 2271136Freely accessible. PMID 15153999.
  46. ↑ International HapMap 3 Consortium; Altshuler, D. M.; Gibbs, R. A.; Peltonen, L.; Altshuler, D. M.; Gibbs, R. A.; Peltonen, L.; Dermitzakis, E.; Schaffner, S. F.; Yu, F.; Peltonen, L.; Dermitzakis, E.; Bonnen, P. E.; Altshuler, D. M.; Gibbs, R. A.; de Bakker, P. I.; Deloukas, P.; Gabriel, S. B.; Gwilliam, R.; Hunt, S.; Inouye, M.; Jia, X.; Palotie, A.; Parkin, M.; Whittaker, P.; Yu, F.; Chang, K.; Hawes, A.; Lewis, L. R.; Ren, Y.; Wheeler, D.; Gibbs, R. A.; Muzny, D. M.; Barnes, C.; Darvishi, K.; Hurles, M.; Korn, J. M.; Kristiansson, K.; Lee, C.; McCarrol, S. A.; Nemesh, J.; Dermitzakis, E.; Keinan, A.; Montgomery, S. B.; Pollack, S.; Price, A. L.; Soranzo, N.; Bonnen, P. E.; Gibbs, R. A.; Gonzaga-Jauregui, C.; Keinan, A.; Price, A. L.; Yu, F.; Anttila, V.; Brodeur, W.; Daly, M. J.; Leslie, S.; McVean, G.; Moutsianas, L.; Nguyen, H.; Schaffner, S. F.; Zhang, Q.; Ghori, M. J.; McGinnis, R.; McLaren, W.; Pollack, S.; Price, A. L.; Schaffner, S. F.; Takeuchi, F.; Grossman, S. R.; Shlyakhter, I.; Hostetter, E. B.; Sabeti, P. C.; Adebamowo, C. A.; Foster, M. W.; Gordon, D. R.; Licinio, J; Manca, M. C ; Marshall, P. A.; Matsuda, I.; Ngare, D.; Wang, V. O.; Reddy, D.; Rotimi, C. N.; Royal, C. D.; Sharp, R. R.; Zeng, C.; Brooks, L. D.; McEwen, J. E. (2 September 2010). "Integrating common and rare genetic variation in diverse human populations". Nature. 467 (7311): 52–58. doi:10.1038/nature09298.
  47. ↑ Licinio, J.; O'Kirwan, F.; Irizarry, K.; Merriman, B.; Thakur, S.; Jepson, R.; Lake, S.; Tantisira, K. G.; Weiss, S. T.; Wong, M.-L. (December 2004). "Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans". Molecular Psychiatry. 9 (12): 1075–1082. doi:10.1038/sj.mp.4001587. PMID 15365580.
  48. ↑ Ribeiro, L.; Busnello, J. V.; Cantor, R. M.; Whelan, F.; Whittaker, P.; Deloukas, P.; Wong, M.-L.; Licinio, J. (6 August 2007). "The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans". NeuroReport. 18 (12): 1291–1293. doi:10.1097/wnr.0b013e328273bcb0. PMC 2686836Freely accessible. PMID 17632285.
  49. ↑ Wu, G. S.; Luo, H. R.; Dong, C.; Mastronardi, C.; Licinio, J.; Wong, M.-L. (May 2009). "Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response". Psychiatric Genetics. 66 (5): 14–18. doi:10.1097/YPG.0b013e32834133d2. PMID 21052032.
  50. ↑ Licinio, J.; Dong, C.; Wong, M.-L. (February 2011). "Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response". Archives of General Psychiatry. 21 (1): 488–497. doi:10.1001/archgenpsychiatry.2009.38.
  51. ↑ Wong, M.-L.; Dong, C.; Flores, D. L.; Ehrhart-Bornstein, M.; Bornstein, S.; Arcos-Burgos, M.; Licinio, J. (15 September 2014). "Clinical Outcomes and Genome-Wide Association for a Brain Methylation Site in an Antidepressant Pharmacogenetics Study in Mexican Americans". American Journal of Psychiatry. 171 (12): 1297–309. doi:10.1176/appi.ajp.2014.12091165. PMID 25220861.
  52. ↑ Licinio, J.; Wong, M.-L. (July 1999). "The role of inflammatory mediators in the biology of major depression: central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection". Molecular Psychiatry. 4 (4): 317–327. doi:10.1038/sj.mp.4000586. PMID 10483047.
  53. ↑ Licinio, J.; Wong, M.-L.; Gold, P. W. (July 1991). "Localization of interleukin-1 receptor antagonist mRNA in rat brain". Endocrinology. 129 (1): 562–564. doi:10.1210/endo-129-1-562. PMID 1829036.
  54. ↑ Licinio, J.; Wong, M.-L. (March 1994). "Localization of interleukin 1 type I receptor mRNA in rat brain". Neuroimmunomodulation. 1 (2): 110–115. PMID 7489320.
  55. ↑ Wong, M.-L.; Rettori, V.; al-Shekhlee, A.; Bongiorno, P. B.; Canteros, G.; McCann, S. M.; Gold, P. W.; Licinio, J. (May 1996). "Inducible nitric oxide synthase gene expression in the brain during systemic inflammation". Nature Medicine. 2 (5): 581–584. doi:10.1038/nm0596-581. PMID 8616720.
  56. ↑ Loddick, S. A.; Wong, M.-L.; Bongiorno, P. B.; Gold, P. W.; Licinio, J.; Rothwell, N. J. (8 May 1997). "Endogenous interleukin-1 receptor antagonist is neuroprotective". Biochemical and Biophysical Research Communications. 234 (1): 211–215. doi:10.1006/bbrc.1997.6436. PMID 9168991.
  57. ↑ Wong, M.-L.; Bongiorno, P. B.; Rettori, V.; McCann, S. M.; Licinio, J.; Wong, M.-L. (7 January 1997). "Interleukin (IL) 1beta, IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: pathophysiological implications". Proceedings of the National Academy of Sciences of the United States of America. 94 (1): 227–232. doi:10.1073/pnas.94.1.227. PMID 8990190.
  58. ↑ Wong, M.-L.; Xie, B.; Beatini, N.; Phu, P., Marathe, S.; Johns, A.; Gold, P. W.; Hirsch, E.; Williams, K. J.; Licinio, J.; Tabas, I. (18 July 2000). "Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesis". Proceedings of the National Academy of Sciences of the United States of America. 97 (15): 8681–8686. doi:10.1073/pnas.150098097. PMID 10890909.
  59. ↑ Mastronardi, C.; Whelan, F.; Yildiz, O. A.; Hannestad, J.; Elashoff, D.; McCann, S. M.; Licinio, J.; Wong, M.-L. (24 April 2007). "Caspase 1 deficiency reduces inflammation-induced brain transcription". Proceedings of the National Academy of Sciences of the United States of America. 104 (17): 7205–7210. doi:10.1073/pnas.0701366104. PMID 17409187.
  60. ↑ "K30 Clinical Research Curriculum Award (CRCA)". NIH. 13 October 2014. Retrieved 13 October 2014.
  61. ↑ "Institutional National Research Service Award". NIH. 13 October 2014. Retrieved 13 October 2014.
  62. ↑ "Physician Scientist Award". NIH. 13 October 2014. Retrieved 13 October 2014.
  63. ↑ "UCLA Interdepartmental Clinical Pharmacology Training Program". UCLA. 13 October 2014. Retrieved 13 October 2014.
  64. ↑ "Midcareer Investigator Award in Patient-Oriented Research". NIH. 13 October 2014. Retrieved 13 October 2014.
  65. ↑ "Professor Julio Licinio – Keynote Address – A sneak peak at the future of psychiatry". Australia National University. 10 July 2011. Retrieved 15 October 2014.
  66. ↑ McGuire, Michael (4 October 2013). "South Australian Health and Medical Research Institute's Julio Licinio delves into the human brain". The Advertiser (Adelaide). Retrieved 15 October 2014.
  67. ↑ "Video-conferência Ciência sem Fronteiras – Prof. Júlio Licínio (Adelaide, Austrália)". Ministry of External Relations (Brazil). Retrieved 15 October 2014.
  68. ↑ Licinio, Julio (21 June 2013). "Diagnosing Madness". Science. Retrieved 15 October 2014.
  69. ↑ Licinio, Julio (23 February 2001). "An Internet Tea Party". Science. Retrieved 15 October 2014.
  70. ↑ Licinio, Julio (1 October 1999). "What Makes One Tic?". Science. Retrieved 15 October 2014.
  71. ↑ Licinio, Julio (18 December 1998). "Expressing Freudian Influences". Science. Retrieved 15 October 2014.
  72. ↑ "Julio Licinio's Blog: Discovery to change your life". 15 October 2014. Retrieved 15 October 2014.
  73. ↑ "Pubmed authors Licinio J and Wong ML". Pubmed. 12 October 2014. Retrieved 12 October 2014.
  74. ↑ Licinio, J.; Wong, M.-L. (February 2005). "Opinion: Depression, antidepressants and suicidality: a critical appraisal". Nature Reviews Drug Discovery. 4 (2): 165–171. doi:10.1038/nrd1634.
  75. ↑ "Pharmacogenomics: The Search for Individualized Therapies". Wiley Online Library. 12 October 2014. Retrieved 12 October 2014.
  76. ↑ "Biology of Depression: From Novel Insights to Therapeutic Strategies". Wiley Online Library. 12 October 2014. Retrieved 12 October 2014.

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