Wierix was born and died in Antwerp. According to Cornelis de Bie's book of artist biographies Het Gulden Cabinet he and his brothers Jan and Antoine were all engravers. His pupils were Abraham van Merlen, Jan Baptist van den Sande the elder, and Jacob de Weert. His daughter Christina married the engraver Jan-Baptist Barbé, who later had his other daughter Cecilia (his sister-in-law) declared insane in order to claim her inheritance, a set of Dürer drawings.
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