HEPPS (molecule)
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| Names | |
|---|---|
| IUPAC name
3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid | |
| Other names
HEPPS, EPPS | |
| Identifiers | |
| 16052-06-5 | |
| 3D model (Jmol) | Interactive image |
| ChEBI | CHEBI:42298  |
| ChemSpider | 76886 |
| ECHA InfoCard | 100.036.528 |
| PubChem | 85255 |
| |
| |
| Properties | |
| C9H20N2O4S | |
| Molar mass | 252.33 g·mol−1 |
| Melting point | (decomposes) |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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| Infobox references | |
HEPPS or EPPS are the common names for the compound 3-[4-(2-Hydroxyethyl)-1-piperazinyl]propanesulfonic acid. It is used as a buffering agent in biology and biochemistry. The pKa of HEPPS is 8.00. Research on mice with Alzheimers disease-like [[Amyloid beta ]] plaques has shown that the EPPS can cause the plaques to break up, reversing some of the symptoms in the mice.[1][2]
References
- ↑ "Small Molecule Breaks Up Amyloid Aggregates In Mice | Chemical & Engineering News". cen.acs.org. Retrieved 14 December 2015.
- ↑ Kim, Hye Yun; Kim, Hyunjin Vincent; Jo, Seonmi; Lee, C. Justin; Choi, Seon Young; Kim, Dong Jin; Kim, YoungSoo (8 December 2015). "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques". Nature Communications. 6: 8997. doi:10.1038/ncomms9997.
External links
- MedicalXpress: Chemical clears Alzheimer's protein and restores memory in mice, last viewed December 10, 2015
See also
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