HDAC10

HDAC10
Identifiers
Aliases HDAC10, HD10, histone deacetylase 10
External IDs MGI: 2158340 HomoloGene: 23749 GeneCards: HDAC10
Targeted by Drug
bufexamac, pracinostat, quisinostat, vorinostat[1]
Orthologs
Species Human Mouse
Entrez

83933

170787

Ensembl

ENSG00000100429

ENSMUSG00000062906

UniProt

Q969S8
Q08AP5

Q6P3E7

RefSeq (mRNA)

NM_032019
NM_001159286

NM_199198

RefSeq (protein)

NP_001152758.1
NP_114408.3

NP_954668.2

Location (UCSC) Chr 22: 50.25 – 50.25 Mb Chr 15: 89.12 – 89.13 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene.[4][5][6]

Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002).[supplied by OMIM][6]

Interactions

HDAC10 has been shown to interact with Histone deacetylase 2[7] and Nuclear receptor co-repressor 2.[7]

See also

References

  1. "Drugs that physically interact with Histone deacetylase 10 view/edit references on wikidata".
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. Kao HY, Lee CH, Komarov A, Han CC, Evans RM (Jan 2002). "Isolation and characterization of mammalian HDAC10, a novel histone deacetylase". J Biol Chem. 277 (1): 187–93. doi:10.1074/jbc.M108931200. PMID 11677242.
  5. Guardiola AR, Yao TP (Jan 2002). "Molecular cloning and characterization of a novel histone deacetylase HDAC10". J Biol Chem. 277 (5): 3350–6. doi:10.1074/jbc.M109861200. PMID 11726666.
  6. 1 2 "Entrez Gene: HDAC10 histone deacetylase 10".
  7. 1 2 Fischer, Denise D; Cai Richard; Bhatia Umesh; Asselbergs Fred A M; Song Chuanzheng; Terry Robert; Trogani Nancy; Widmer Roland; Atadja Peter; Cohen Dalia (Feb 2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10". J. Biol. Chem. United States. 277 (8): 6656–66. doi:10.1074/jbc.M108055200. ISSN 0021-9258. PMID 11739383.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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