HARS2

HARS2
Identifiers
Aliases	HARS2, HARSL, HARSR, HO3, PRLTS2, histidyl-tRNA synthetase 2, mitochondrial
External IDs	MGI: 1918041 HomoloGene: 40819 GeneCards: HARS2
Gene ontology Molecular function • aminoacyl-tRNA ligase activity • nucleotide binding • poly(A) RNA binding • ligase activity • protein binding • ATP binding • protein homodimerization activity • histidine-tRNA ligase activity Cellular component • cytoplasm • mitochondrial matrix • mitochondrion Biological process • translation • histidyl-tRNA aminoacylation • mitochondrial translation • tRNA aminoacylation for protein translation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23438	70791
Ensembl	ENSG00000112855	ENSMUSG00000019143
UniProt	P49590	Q99KK9
RefSeq (mRNA)	NM_001278731 NM_001278732 NM_012208	NM_080636 NM_001305627
RefSeq (protein)	NP_001265660.1 NP_001265661.1 NP_036340.1	NP_542367.1
Location (UCSC)	Chr 5: 140.69 – 140.7 Mb	Chr 18: 36.78 – 36.79 Mb
PubMed search	[1]	[2]
Wikidata

Probable histidyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the HARS2 gene.^[3][4]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter.^[4]

References

Further reading