Glycineamide ribonucleotide

Glycineamide ribonucleotide

Names
IUPAC name [(2R,3S,4R,5R)-5-[(2-aminoacetyl)amino]-3,4-dihydroxyoxolan-2-yl]methyldihydrogen phosphate
Other names Glycineamide ribotide, GAR
Identifiers
CAS Number	10074-18-7 Y
3D model (Jmol)	Interactive image
ChemSpider	141370
MeSH	Glycineamide+ribonucleotide
PubChem	160913
InChI InChI=1S/C7H15N2O8P/c8-1-4(10)9-7-6(12)5(11)3(17-7)2-16-18(13,14)15/h3,5-7,11-12H,1-2,8H2,(H,9,10)(H2,13,14,15)/t3-,5-,6-,7-/m1/s1 Key: OBQMLSFOUZUIOB-SHUUEZRQSA-N
SMILES C([C@@H]1[C@H]([C@H]([C@@H](O1)NC(=O)CN)O)O)OP(=O)(O)O
Properties
Chemical formula	C7H15N2O8P
Molar mass	286.18 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Glycineamide ribonucleotide (or GAR) is an intermediate in de novo purine biosynthesis.

It is formed from phosphoribosylamine by the enzyme phosphoribosylamine—glycine ligase. In the next step of purine biosynthesis the enzyme phosphoribosylglycinamide formyltransferase acts on GAR to form FGAR.

GAR formation is stimulated by Luteinizing hormone (LH) and Chorionic gonadotropin (HCG) via activation of Glc-6-P-dehydrogenase (EC 1.1.1.49)^[1][2]

Synonyms

Several names are associated with GAR:

• 5'-p-Ribosylglycinamide
• 5'-p-Ribosylglycineamide
• 5'-Phosphoribosyl-glycineamide
• 5'-Phosphoribosylglycinamide
• 5'-Phosphoribosylglycineamide
• Glycineamide ribotide
• Glycinamide ribonucleotide
• Glycineamide ribonucleotide
• N(1)-(5-Phospho-D-ribosyl)glycinamide
• N-Glycyl-5-O-phosphono-D-ribofuranosylamine
• N1-(5-phospho-D-ribosyl)glycinamide

References

1. ↑ "SMPDB: Glycineamideribotide". August 24, 2015. 
2. ↑ "Human Metabolome Database: Glycineamideribotide". August 24, 2015.