Gerald Weissmann

Gerald Weissmann is an American physician/scientist, editor and essayist. He is Professor Emeritus and Research Professor of Medicine (Rheumatology) at New York University School of Medicine. He was Editor-in-Chief (2006–16) of The FASEB Journal.[1] He is now its Book Review editor.

Gerald Weissmann

Early life and education

Weissmann was born in Vienna, Austria on August 7, 1930, to Adolf and Greta Weissmann.[2] He immigrated to the United States in 1938, and became a naturalized American citizen in 1943. After the Bronx High School of Science, he received a B.A. from Columbia University in 1950 and his M.D. from New York University in 1954. He also pursued an early career in art, exhibiting at a major New York gallery.[3]

Career

After clinical training at the Mt. Sinai Hospital, New York in New York City and active service as captain in the U.S. Army Medical Corps, he took a research fellowship in the Department of Biochemistry at NYU (1958–59) under Nobel laureate, Severo Ochoa. Lewis Thomas then selected him as Chief Medical Resident at Bellevue Hospital Center (1959–60). Weissmann next worked at the Strangeways Research Laboratory, Cambridge England, studying cell biology under Dame Honor B. Fell to 1962. He returned to N.Y.U. School of Medicine, and has been on its faculty to date. In 1964 and 1969, he was a visiting investigator at the A.R.C. Institute of Animal Physiology, Babraham (Cambridge), England; in 1973-1974 he was awarded a Guggenheim Foundation scholarship at the Centre de Physiologie et d'Immunologie Cellulaires, Hopital Saint Antoine, Paris, as a visiting investigator; and as visiting fellow at the William Harvey Research Institute, London in 1987.[2][4] Weissmann became Professor of Medicine at N.Y.U. in 1970, and served as Director of the Division of Rheumatology from 1973 to 1999. From 1970 to date, he has spent summers as an investigator and lecturer and has served for 18 years as a trustee (now emeritus) at the Marine Biological Laboratory, Woods Hole, MA.[5] He is best known for having presented evidence that rheumatoid arthritis is an immune complex disease (provoked perhaps by genetic programs that misdirect immune responses to oral bacteria).[6][7] His laboratory found that crises in Systemic Lupus Erythematosus are provoked by intravascular complement activation.[8] He has also pioneered studies in leukocyte activation (via C5a, immune complexes, etc.), the role of salicylates and corticosteroids in cell signalling and adhesion (MAP kinases, erk 1-2, MEK, NFKappaB).[9]

He is responsible for the codiscovery of Liposomes in 1965 and credited with coining that name by the Oxford Dictionary of the English Language (1965). He was a founder (with E.C. Whitehead) and a director of the Liposome Company, Inc. from 1982 to 2000, and two drugs based on his liposome work are now in the clinic (Abelcet and Myocet).[10][11] There are now over 52,000 references to liposomes on PubMed. Dr. Weissmann has received the Lila Gruber Award for Cancer Research two residencies at the Rockefeller Foundation Study Center at Bellagio, the Allesandro Robecchi and Paul Klemperer awards for inflammation research, as well as the Distinguished Investigator and Presidential Gold Medal Awards of the American College of Rheumatology He is a foreign member of the Accademia Nazionale dei Lincei of Rome and the Royal Society of Medicine of London. He is a Master and past president of the American College of Rheumatology, a past president of the Harvey Society, a Fellow of the AAAS, The New York Academy of Medicine and The New York Academy of Sciences. With the late Joshua Lederberg, he was a founding member of the advisory boards of the Pew Scholars in Biomedical Sciences, the Ellison Medical Foundation and was the founding chairman of the jury for the Prix Galien USA.[5]

Editorial activities

From 1975-2001, Weissmann was the founding editor of the journal, Inflammation; he edited MD Magazine from 1979-1984, and from 2006 to 2016 has served as the Editor-in-Chief of The FASEB Journal.

Essays

A member of PEN, his essays and reviews of cultural history have been published in The New Republic, the London Review of Books, and The New York Times Review of Books, and have been collected in ten volumes,from The Woods Hole Cantata (1985) to Epigenetics in the Age of Twitter: Pop Culture and Modern Science (2012).His work has been praised for scientific insight by Jonas Salk, for literary style by Kurt Vonnegut, and for breadth of general culture by Adam Gopnik.

Personal life

He has been married to Ann (Raphael) Weissmann since 1953, and has two children, Lisa Beth Weissmann, MD of Mount Auburn Hospital Cambridge, MA and Andrew Weissmann, Esq. of the U.S. Department of Justice in Washington, D.C.

References

  1. ↑ http://www.fasebj.org/site/misc/edboard.xhtml
  2. 1 2 http://www.highbeam.com/doc/1G2-3415600174.html
  3. ↑ "Youthful Painter Gives Exhibition" New York Times December 17, 1949 p 15
  4. ↑ http://www.gf.org/fellows/all-fellows/gerald-weissmann/
  5. 1 2 https://www.youtube.com/watch?v=g--IiIx8PlY
  6. ↑ Goldstein, I.M., Roos, D., Kaplan, H., and Weissmann, G., Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis, J. Clin. Invest., 56:1155-1163, 1975.
  7. ↑ Rosenstein ED, Greenwald RA, Kushner LJ, Weissmann G. Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. Inflammation 28:311-318 2004.
  8. ↑ Abramson, S.B., Belmont, H.M., Hopkins, P., Buyon, J., Winchester, R. and Weissmann, G. Complement activation and vascular injury in systemic lupus erythematosus. J. Rheumatology. 14:43-46, 1987.
  9. ↑ Kimmel, S.C., Cronstein, B.N., Levin, R.I., and Weissmann, G. A mechanism for the antiinflammatory effects of corticosteroids: The glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of ELAM-1 and ICAM-1. Proc. Nat'l. Acad. Sci. U.S.A., 89:9991-9995, 1992.
  10. ↑ Bangham, A.D., Standish, M.M. and Weissmann, G., The action of steroids and streptolysin S on the permeability of phospholipid structures to cations, J. Mol. Biol., 13:253-259, 1965.
  11. ↑ Sessa, G. and Weissmann, G., Phospholipid spherules (liposomes) as a model for biological membranes, J. Lipid Res., 9:310-318, 1968.
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