Galnon
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| Identifiers | |
|---|---|
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| CAS Number |
475115-35-6  |
| PubChem (CID) | 5311268 |
| IUPHAR/BPS | 6118 |
| ChemSpider |
4470781  |
| ChEMBL |
CHEMBL592414 |
| Chemical and physical data | |
| Formula | C40H46N4O6 |
| Molar mass | 678.815 |
| 3D model (Jmol) | Interactive image |
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| (what is this?) (verify) | |
Galnon is a drug which acts as a selective, non-peptide agonist at the galanin receptors GALR.[1][2] It has anticonvulsant, anxiolytic, anorectic and amnestic effects in animal studies.[3][4][5][6][7]
References
- ↑ Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, Hellberg S, Pooga M, Tolf BR, Shi TS, Hökfelt T, Wasterlain C, Bartfai T, Langel U (May 2002). "Anticonvulsant activity of a nonpeptide galanin receptor agonist". Proceedings of the National Academy of Sciences of the United States of America. 99 (10): 7136–41. doi:10.1073/pnas.102163499. PMC 124541
. PMID 12011470. - ↑ Sollenberg U, Bartfai T, Langel U (June 2005). "Galnon--a low-molecular weight ligand of the galanin receptors". Neuropeptides. 39 (3): 161–3. doi:10.1016/j.npep.2004.12.019. PMID 15944006.
- ↑ Abramov U, Florén A, Echevarria DJ, Brewer A, Manuzon H, Robinson JK, Bartfai T, Vasar E, Langel U (February 2004). "Regulation of feeding by galnon". Neuropeptides. 38 (1): 55–61. doi:10.1016/j.npep.2004.01.001. PMID 15003717.
- ↑ Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T (June 2005). "Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice". Neuropeptides. 39 (3): 249–51. doi:10.1016/j.npep.2004.12.010. PMID 15944018.
- ↑ Rajarao SJ, Platt B, Sukoff SJ, Lin Q, Bender CN, Nieuwenhuijsen BW, Ring RH, Schechter LE, Rosenzweig-Lipson S, Beyer CE (October 2007). "Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon". Neuropeptides. 41 (5): 307–20. doi:10.1016/j.npep.2007.05.001. PMID 17637475.
- ↑ Kozlovsky N, Matar MA, Kaplan Z, Zohar J, Cohen H (March 2009). "The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder". Biological Psychiatry. 65 (5): 383–91. doi:10.1016/j.biopsych.2008.10.034. PMID 19095221.
- ↑ Narasimhaiah R, Kamens HM, Picciotto MR (May 2009). "Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice". Psychopharmacology. 204 (1): 95–102. doi:10.1007/s00213-008-1438-7. PMC 2872184. PMID 19099295.
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