GUK1

GUK1

Identifiers

GUK1, GMK, guanylate kinase 1

External IDs

MGI: 95871 HomoloGene: 665 GeneCards: GUK1

Gene ontology
Molecular function	• ATP binding • kinase activity • nucleotide binding • transferase activity • guanylate kinase activity
Cellular component	• cytosol
Biological process	• dGMP metabolic process • purine nucleotide metabolic process • nucleobase-containing small molecule interconversion • glycoprotein transport • GMP metabolic process • ATP metabolic process • nucleotide phosphorylation • GDP biosynthetic process • dGDP biosynthetic process • dATP metabolic process • phosphorylation • GDP-mannose metabolic process • GDP metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


2987


14923


ENSG00000143774


ENSMUSG00000020444


Q16774 Q6IBG8


Q64520

RefSeq (mRNA)


NM_000858 NM_001159390 NM_001159391 NM_001242839 NM_001242840


NM_001159410 NM_008193

RefSeq (protein)

NP_000849.1 NP_001152862.1 NP_001152863.1 NP_001229768.1 NP_001229769.1
NP_000849.1 NP_001152862.1 NP_001152863.1 NP_001229768.1


XP_006532308.1 XP_006532309.1

Location (UCSC)

Chr 1: 228.14 – 228.15 Mb

Chr 11: 59.18 – 59.19 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Guanylate kinase is an enzyme that in humans is encoded by the GUK1 gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Fitzgibbon J, Katsanis N, Wells D, Delhanty J, Vallins W, Hunt DM (Jul 1996). "Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation". FEBS Lett. 385 (3): 185–188. doi:10.1016/0014-5793(96)00365-1. PMID 8647247.
↑ "Entrez Gene: GUK1 guanylate kinase 1".

Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brady WA, Kokoris MS, Fitzgibbon M, Black ME (1996). "Cloning, characterization, and modeling of mouse and human guanylate kinases". J. Biol. Chem. 271 (28): 16734–40. doi:10.1074/jbc.271.28.16734. PMID 8663313.
Boritzki TJ, Jackson RC, Morris HP, Weber G (1981). "Guanosine-5'-phosphate synthetase and guanosine-5'-phosphate kinase in rat hepatomas and kidney tumors". Biochim. Biophys. Acta. 658 (1): 102–110. doi:10.1016/0005-2744(81)90253-9. PMID 6260205.
Dallapiccola B, Lungarotti MS, Falorni A, et al. (1980). "Evidence for the assignment of GUK 1 gene locus to 1q32 leads to q43 segment from gene dosage effect". Ann. Genet. 23 (2): 83–85. PMID 6249178.
Savitskiĭ IV (1990). "[Increase in 5'-nucleotidase and decrease in guanylate kinase activity in the brain and liver of irradiated rats]". Ukr. Biokhim. Zh. 62 (2): 110–114. PMID 2164269.
Agarwal KC, Miech RP, Parks RE (1978). "Guanylate kinases from human erythrocytes, hog brain, and rat liver". Meth. Enzymol. Methods in Enzymology. 51: 483–490. doi:10.1016/S0076-6879(78)51066-5. ISBN 978-0-12-181951-4. PMID 211390.

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