She married Sir Richard Myddelton, 3rd Baronet (1655–1716) in c.1686. They had three children:
- Frances Myddelton (d.1693),
- Mary Myddelton (1688–1747),
- Sir William Myddelton, 4th Baronet (1694–1718).
As one of the Hampton Court Beauties, Frances Myddelton (Nee Whitmore) was known as Lady Myddelton, coincidentally, her husband's aunt is the Mrs Myddelton of the Windsor Beauties and her own mother is Lady Whitmore of the Windsor Beauties.