ERRFI1

ERRFI1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases ERRFI1, GENE-33, MIG-6, MIG6, RALT, ERBB receptor feedback inhibitor 1
External IDs MGI: 1921405 HomoloGene: 10344 GeneCards: ERRFI1
Orthologs
Species Human Mouse
Entrez

54206

74155

Ensembl

ENSG00000116285

ENSMUSG00000028967

UniProt

Q9UJM3

Q99JZ7

RefSeq (mRNA)

NM_018948

NM_133753

RefSeq (protein)

NP_061821.1

NP_598514.1

Location (UCSC) Chr 1: 8 – 8.03 Mb Chr 4: 150.85 – 150.87 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene.[3][4][5][6][7]

MIG6 is a Cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000).[supplied by OMIM][7]

Interactions

ERRFI1 has been shown to interact with Stratifin[8] and CDC42.[3]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. 1 2 Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM (Jul 2000). "Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress". J Biol Chem. 275 (23): 17838–17847. doi:10.1074/jbc.M909735199. PMID 10749885.
  4. Chrapkiewicz NB, Davis CM, Chu DT, Caldwell CM, Granner DK (Oct 1989). "Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity". Nucleic Acids Res. 17 (16): 6651–6667. doi:10.1093/nar/17.16.6651. PMC 318357Freely accessible. PMID 2780291.
  5. Fiorini M, Ballaro C, Sala G, Falcone G, Alema S, Segatto O (Sep 2002). "Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control". Oncogene. 21 (42): 6530–6539. doi:10.1038/sj.onc.1205823. PMID 12226756.
  6. Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alema S, Benedetti P, Segatto O (Oct 2000). "Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain". Mol Cell Biol. 20 (20): 7735–7750. doi:10.1128/MCB.20.20.7735-7750.2000. PMC 86354Freely accessible. PMID 11003669.
  7. 1 2 "Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1".
  8. Benzinger, Anne; Muster Nemone; Koch Heike B; Yates John R; Hermeking Heiko (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics. United States. 4 (6): 785–795. doi:10.1074/mcp.M500021-MCP200. ISSN 1535-9476. PMID 15778465.

Further reading


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