Diapocynin
 | |
| Names | |
|---|---|
| IUPAC name
1,1′-(6,6′-Dihydroxy-5,5′-dimethoxy[1,1′-biphenyl]-3,3′-diyl)bis-ethanone | |
| Other names
Diapocynin, 4',4-Dihydroxy-5',5-dimethoxy-3',3-biacetophenone | |
| Identifiers | |
| 29799-22-2 | |
| 3D model (Jmol) | Interactive image |
| ChemSpider | 8103122 |
| ECHA InfoCard | 100.233.239 |
| |
| |
| Properties | |
| C18H18O6 | |
| Molar mass | 330.34 g·mol−1 |
| Appearance | brown color |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Diapocynin is a dimer of apocynin.
Synthesis
Diapocynin is synthesized by the activation of apocynin with ferrous sulfate and sodium persulfate.[1] Similar to apocynin, it is shown to have some beneficial effects against oxidative stress and reducing reactive oxygen species,.[2][3]
References
- ↑ "Synthesis of diapocynin." Journal of chemical education 85, no. 3 (2008): 411.
- ↑ Dranka, B. P., Gifford, A., Ghosh, A., Zielonka, J., Joseph, J., Kanthasamy, A. G., & Kalyanaraman, B. (2013). Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2 R1441G) transgenic mouse. Neuroscience letters, 549, 57-62.
- ↑ Ismail, Hesham M.; Scapozza, Leonardo; Ruegg, Urs T.; Dorchies, Olivier M. (17 October 2014). "Diapocynin, a Dimer of the NADPH Oxidase Inhibitor Apocynin, Reduces ROS Production and Prevents Force Loss in Eccentrically Contracting Dystrophic Muscle". PLoS ONE. 9 (10): e110708. doi:10.1371/journal.pone.0110708.
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