Denaverine

Denaverine
Clinical data

AHFS/Drugs.com	International Drug Names
Pregnancy category	Gr 1 (Germany)
Routes of administration	intramuscular injection, suppositories
ATCvet code	QG02CX90 (WHO)
Legal status
Legal status	℞ (Prescription only)
Pharmacokinetic data
Bioavailability	8% (suppositories), 37% (oral solution)
Metabolism	mainly hepatic, at least 11 metabolites
Biological half-life	34 hours
Identifiers
IUPAC name 2-(Dimethylamino)ethyl (2-ethylbutoxy)diphenylacetate
CAS Number	3579-62-2^Y 3321-06-0 (hydrochloride)
PubChem (CID)	71130
ChemSpider	64278^N
UNII	O14NF38MTL^Y
KEGG	D07787^Y
ChEMBL	CHEMBL1614656^N
Chemical and physical data
Formula	C₂₄H₃₃NO₃
Molar mass	383.52 g/mol
3D model (Jmol)	Interactive image
SMILES CCC(CC)COC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OCCN(C)C
InChI InChI=1S/C24H33NO3/c1-5-20(6-2)19-28-24(21-13-9-7-10-14-21,22-15-11-8-12-16-22)23(26)27-18-17-25(3)4/h7-16,20H,5-6,17-19H2,1-4H3^N Key:FPTOUQZVCUIPHY-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Denaverine is an antispasmodic drug. It was developed in Germany and patented in 1974. Denaverine hydrochloride is used in veterinary medicine under the trade name Sensiblex as a muscle relaxant for the myometrium of cows and dogs during childbirth.^[1] Under the trade name Spasmalgan, it has also been used in humans for the treatment of urogenital and gastrointestinal spasms.^[2]

Mechanism of action

Denaverine, like papaverine, acts as a phosphodiesterase inhibitor. Additionally, it has anticholinergic effects.^[3]

References

↑ Committee for Veterinary Medicinal Products: Denavering Hydrochloride Summary Report
↑ Dootz, H; Kuhlmann, A; Hoffmann, K (eds.). Rote Liste (in German) (2005 ed.). Aulendorf: Editio Cantor. 77 023. ISBN 3-87193-306-6.
↑ Dinnendahl, V; Fricke, U, eds. (2010). Arzneistoff-Profile (in German). 4 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.

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