Chlorzoxazone

Chlorzoxazone
Clinical data
Trade names Parafonforte
AHFS/Drugs.com Monograph
MedlinePlus a682577
Routes of
administration		 oral
ATC code M03BB03 (WHO)
Pharmacokinetic data
Bioavailability well absorbed
Protein binding 13–18%
Metabolism hepatic
Biological half-life 1.1 hr
Excretion urine (<1%)
Identifiers
CAS Number 95-25-0 YesY
PubChem (CID) 2733
IUPHAR/BPS 2322
DrugBank DB00356 YesY
ChemSpider 2632 YesY
UNII H0DE420U8G YesY
KEGG D00771 YesY
ChEBI CHEBI:3655 YesY
ChEMBL CHEMBL1371 YesY
ECHA InfoCard 100.002.186
Chemical and physical data
Formula C7H4ClNO2
Molar mass 169.565 g/mol
3D model (Jmol) Interactive image
  (verify)

Chlorzoxazone (INN) is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes. It is sold under the trade names "Lorzone", Paraflex and Muscol and in combination form as Parafon Forte, a combination of chlorzoxazone and acetaminophen (paracetamol). Possible side effects include dizziness, lightheadedness, malaise, nausea, vomiting, and liver dysfunction. Used with acetaminophen it has added risk of hepatoxicity, which is why the combination is not recommended. It can also be administered for acute pain in general and for tension headache (muscle contraction headache).

As of 2015 the cost for a typical course of medication in the United States is less than 25 USD.[1]

See also

References

  1. ↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 1. ISBN 9781284057560.



This article is issued from Wikipedia - version of the 6/16/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.