Cefmetazole

Cefmetazole
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a601206
ATC code J01DC09 (WHO)
Identifiers
CAS Number 56796-20-4 YesY
PubChem (CID) 42008
DrugBank DB00274 YesY
ChemSpider 38311 YesY
UNII 3J962UJT8H YesY
KEGG D00910 YesY
ChEBI CHEBI:3489 YesY
ChEMBL CHEMBL1201195 N
ECHA InfoCard 100.054.877
Chemical and physical data
Formula C15H17N7O5S3
Molar mass 471.538 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Cefmetazole is a cephamycin antibiotic, usually grouped with the second-generation cephalosporins.

Adverse effects

The chemical structure of cefmetazole, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (Antabuse®), due to inhibition of aldehyde dehydrogenase.[1]

Spectrum of bacterial susceptibility

Cefmetazole is a broad-spectrum cephalosporin antimicrobial and has been effective in treating bacteria responsible for causing urinary tract and skin infections. The following represents MIC susceptibility data for a few medically significant microorganisms.

[2]

References

  1. Stork CM (2006). "Antibiotics, antifungals, and antivirals". In Nelson LH, Flomenbaum N, Goldfrank LR, Hoffman RL, Howland MD, Lewin NA. Goldfrank's toxicologic emergencies. New York: McGraw-Hill. p. 847. ISBN 0-07-143763-0. Retrieved 2009-07-03.
  2. http://www.toku-e.com/Assets/MIC/Cefmetazole%20free%20acid.pdf


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