CYC1

CYC1

Identifiers

CYC1, MC3DN6, UQCR4, cytochrome c1

External IDs

MGI: 1913695 HomoloGene: 55617 GeneCards: CYC1

Gene ontology
Molecular function	• electron carrier activity • electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity • heme binding • metal ion binding
Cellular component	• integral component of membrane • respiratory chain • nucleus • mitochondrion • mitochondrial inner membrane • membrane
Biological process	• response to glucagon • oxidation-reduction process • mitochondrial electron transport, ubiquinol to cytochrome c
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


1537


66445


ENSG00000179091


ENSMUSG00000022551


P08574


Q9D0M3

RefSeq (mRNA)


NM_001916


NM_025567

RefSeq (protein)


NP_001907.2


NP_079843.1

Location (UCSC)

Chr 8: 144.1 – 144.1 Mb

Chr 15: 76.34 – 76.35 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Cytochrome c1, heme protein, mitochondrial is a protein that in humans is encoded by the CYC1 gene.^[3]

References

Further reading

Moon HS, Yang JS (2006). "Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells.". Mol. Cells. 21 (1): 7–20. PMID 16511342.
Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T (1989). "Structural organization of the human mitochondrial cytochrome c1 gene.". J. Biol. Chem. 264 (3): 1368–74. PMID 2536365.
Nishikimi M, Ohta S, Suzuki H, et al. (1988). "Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1". Nucleic Acids Res. 16 (8): 3577. doi:10.1093/nar/16.8.3577. PMC 336517. PMID 2836796.
Tanaka Y, Ashikari T, Shibano Y, et al. (1988). "Construction of a human cytochrome c gene and its functional expression in Saccharomyces cerevisiae". J. Biochem. 103 (6): 954–61. PMID 2844747.
Shimomura Y, Nishikimi M, Ozawa T (1986). "Novel purification of cytochrome c1 from mitochondrial Complex III. Reconstitution of antimycin-insensitive electron transfer with the iron-sulfur protein and cytochrome c1". J. Biol. Chem. 260 (28): 15075–80. PMID 2999105.
Nishikimi M, Suzuki H, Ohta S, et al. (1987). "Isolation of a cDNA clone for human cytochrome c1 from a lambda gt11 expression library". Biochem. Biophys. Res. Commun. 145 (1): 34–9. doi:10.1016/0006-291X(87)91283-6. PMID 3036122.
Smith HT, Ahmed AJ, Millett F (1981). "Electrostatic interaction of cytochrome c with cytochrome c1 and cytochrome oxidase". J. Biol. Chem. 256 (10): 4984–90. PMID 6262312.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Duncan AM, Ozawa T, Suzuki H, Rozen R (1994). "Assignment of the gene for the cytochrome c1 subunit of the mitochondrial cytochrome bc1 complex (CYC1) to human chromosome 8q24.3". Genomics. 19 (2): 400–1. doi:10.1006/geno.1994.1084. PMID 8188279.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Valnot I, Kassis J, Chretien D, et al. (1999). "A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency". Hum. Genet. 104 (6): 460–6. doi:10.1007/s004390050988. PMID 10453733.
Jacotot E, Ferri KF, El Hamel C, et al. (2001). "Control of Mitochondrial Membrane Permeabilization by Adenine Nucleotide Translocator Interacting with HIV-1 Viral Protein R and Bcl-2". J. Exp. Med. 193 (4): 509–19. doi:10.1084/jem.193.4.509. PMC 2195906. PMID 11181702.
Tafani M, Karpinich NO, Hurster KA, et al. (2002). "Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition". J. Biol. Chem. 277 (12): 10073–82. doi:10.1074/jbc.M111350200. PMID 11790791.
Muthumani K, Hwang DS, Desai BM, et al. (2002). "HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells". J. Biol. Chem. 277 (40): 37820–31. doi:10.1074/jbc.M205313200. PMID 12095993.
Muthumani K, Zhang D, Hwang DS, et al. (2002). "Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines". Oncogene. 21 (30): 4613–25. doi:10.1038/sj.onc.1205549. PMID 12096338.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brenner C, Kroemer G (2003). "The mitochondriotoxic domain of Vpr determines HIV-1 virulence". J. Clin. Invest. 111 (10): 1455–7. doi:10.1172/JCI18609. PMC 155055. PMID 12750393.
Lum JJ, Cohen OJ, Nie Z, et al. (2003). "Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis". J. Clin. Invest. 111 (10): 1547–54. doi:10.1172/JCI16233. PMC 155040. PMID 12750404.
Yuan J, Murrell GA, Trickett A, Wang MX (2003). "Involvement of cytochrome c release and caspase-3 activation in the oxidative stress-induced apoptosis in human tendon fibroblasts". Biochim. Biophys. Acta. 1641 (1): 35–41. doi:10.1016/S0167-4889(03)00047-8. PMID 12788227.
An J, Chen Y, Huang Z (2004). "Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor". J. Biol. Chem. 279 (18): 19133–40. doi:10.1074/jbc.M400295200. PMID 14966123.

PDB gallery

1bcc: CYTOCHROME BC1 COMPLEX FROM CHICKEN

1be3: CYTOCHROME BC1 COMPLEX FROM BOVINE

1bgy: CYTOCHROME BC1 COMPLEX FROM BOVINE

1l0l: structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone

1l0n: native structure of bovine mitochondrial cytochrome bc1 complex

1ntk: Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1

1ntm: Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom

1ntz: Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone

1nu1: Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO)

1pp9: Bovine cytochrome bc1 complex with stigmatellin bound

1ppj: Bovine cytochrome bc1 complex with stigmatellin and antimycin

1sqb: Crystal Structure Analysis of Bovine Bc1 with Azoxystrobin

1sqp: Crystal Structure Analysis of Bovine Bc1 with Myxothiazol

1sqq: Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS)

1sqv: Crystal Structure Analysis of Bovine Bc1 with UHDBT

1sqx: Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A

2a06: Bovine cytochrome bc1 complex with stigmatellin bound

2bcc: STIGMATELLIN-BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN

2fyu: Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor

3bcc: STIGMATELLIN AND ANTIMYCIN BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN

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