CRABP1

Identifiers

CRABP1, CRABP, CRABP-I, CRABPI, RBP5, cellular retinoic acid binding protein 1

External IDs

MGI: 88490 HomoloGene: 3222 GeneCards: CRABP1

Gene ontology
Molecular function	• retinol binding • retinoic acid binding • protein binding • retinoid binding • retinal binding • lipid binding • transporter activity
Cellular component	• cytoplasm • cytosol
Biological process	• multicellular organism development • retinoic acid catabolic process • signal transduction • transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1381


12903

Ensembl


ENSG00000166426


ENSMUSG00000032291

UniProt


P29762


P62965

RefSeq (mRNA)


NM_004378


NM_001284507 NM_013496

RefSeq (protein)


NP_004369.1


NP_038524.1

Location (UCSC)

Chr 15: 78.34 – 78.35 Mb

Chr 9: 54.76 – 54.77 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Cellular retinoic acid-binding protein 1 is a protein that in humans is encoded by the CRABP1 gene.^[3]^[4]

A number of specific carrier proteins for members of the vitamin A family have been discovered. Cellular retinoic acid-binding protein is assumed to play an important role in retinoic acid-mediated differentiation and proliferation processes. CRABP1 is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid. CRABP1 is constitutively expressed and is believed to have different functions in the cell than the related CRABP2.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Flagiello D, Apiou F, Gibaud A, Poupon MF, Dutrillaux B, Malfoy B (Jun 1997). "Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization". Cytogenet Cell Genet. 76 (1–2): 17–8. doi:10.1159/000134502. PMID 9154115.
1 2 "Entrez Gene: CRABP1 cellular retinoic acid binding protein 1".

Eller MS, Oleksiak MF, McQuaid TJ, et al. (1992). "The molecular cloning and expression of two CRABP cDNAs from human skin". Exp. Cell Res. 198 (2): 328–36. doi:10.1016/0014-4827(92)90387-N. PMID 1309505.
Aström A, Tavakkol A, Pettersson U, et al. (1991). "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro". J. Biol. Chem. 266 (26): 17662–6. PMID 1654334.
Ong DE (1987). "Cellular retinoid-binding proteins". Archives of dermatology. 123 (12): 1693–1695a. doi:10.1001/archderm.123.12.1693. PMID 2825608.
Wang L, Li Y, Yan H (1997). "Structure-function relationships of cellular retinoic acid-binding proteins. Quantitative analysis of the ligand binding properties of the wild-type proteins and site-directed mutants". J. Biol. Chem. 272 (3): 1541–7. doi:10.1074/jbc.272.3.1541. PMID 8999826.
Liu W, Hellman P, Li Q, et al. (1997). "Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells". Biochem. Biophys. Res. Commun. 229 (3): 922–9. doi:10.1006/bbrc.1996.1903. PMID 9005841.
Kreutz M, Fritsche J, Andreesen R, Krause SW (1998). "Regulation of cellular retinoic acid binding protein (CRABP II) during human monocyte differentiation in vitro". Biochem. Biophys. Res. Commun. 248 (3): 830–4. doi:10.1006/bbrc.1998.9058. PMID 9704013.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Huang Y, de la Chapelle A, Pellegata NS (2003). "Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma". Int. J. Cancer. 104 (6): 735–44. doi:10.1002/ijc.11006. PMID 12640681.
Kim SK, Yoo JI, Cho BK, et al. (2004). "Elevation of CRABP-I in the cerebrospinal fluid of patients with Moyamoya disease". Stroke. 34 (12): 2835–41. doi:10.1161/01.STR.0000100159.43123.D7. PMID 14605320.
Blaese MA, Santo-Hoeltje L, Rodemann HP (2004). "CRABP I expression and the mediation of the sensitivity of human tumour cells to retinoic acid and irradiation". Int. J. Radiat. Biol. 79 (12): 981–91. doi:10.1080/09553000310001632949. PMID 14713576.
Won JY, Nam EC, Yoo SJ, et al. (2004). "The effect of cellular retinoic acid binding protein-I expression on the CYP26-mediated catabolism of all-trans retinoic acid and cell proliferation in head and neck squamous cell carcinoma". Metab. Clin. Exp. 53 (8): 1007–12. doi:10.1016/j.metabol.2003.12.015. PMID 15281009.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ahn J, Chung KS, Kim DU, et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus". J. Biochem. Mol. Biol. 37 (6): 741–8. PMID 15607035.
Pfoertner S, Goelden U, Hansen W, et al. (2005). "Cellular retinoic acid binding protein I: expression and functional influence in renal cell carcinoma". Tumour Biol. 26 (6): 313–23. doi:10.1159/000089262. PMID 16254461.
Lind GE, Kleivi K, Meling GI, et al. (2007). "ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis". Cell. Oncol. 28 (5–6): 259–72. PMID 17167179.
Tanaka K, Imoto I, Inoue J, et al. (2007). "Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma". Oncogene. 26 (44): 6456–68. doi:10.1038/sj.onc.1210459. PMID 17438526.
Wu Q, Lothe RA, Ahlquist T, et al. (2007). "DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets". Mol. Cancer. 6: 45. doi:10.1186/1476-4598-6-45. PMC 1964763. PMID 17623056.

PDB gallery

1cbi: APO-CELLULAR RETINOIC ACID BINDING PROTEIN I

1cbr: CRYSTAL STRUCTURE OF CELLULAR RETINOIC-ACID-BINDING PROTEINS I AND II IN COMPLEX WITH ALL-TRANS-RETINOIC ACID AND A SYNTHETIC RETINOID

2cbr: CELLULAR RETINOIC ACID BINDING PROTEIN I IN COMPLEX WITH A RETINOBENZOIC ACID (AM80)

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CRABP1

References

Further reading