Collagen, type IV, alpha 2

Available structures
PDBOrtholog search: PDBe RCSB
Aliases COL4A2, ICH, POREN2, collagen type IV alpha 2
External IDs MGI: 88455 HomoloGene: 1390 GeneCards: COL4A2
RNA expression pattern

More reference expression data
Species Human Mouse









RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 13: 110.31 – 110.51 Mb Chr 8: 11.31 – 11.45 Mb
PubMed search [1] [2]
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Collagen alpha-2(IV) chain is a protein that in humans is encoded by the COL4A2 gene.[3][4][5]

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.[5]


  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Myers JC, Howard PS, Jelen AM, Dion AS, Macarak EJ (Aug 1987). "Duplication of type IV collagen COOH-terminal repeats and species-specific expression of alpha 1(IV) and alpha 2(IV) collagen genes". J Biol Chem. 262 (19): 9231–8. PMID 2439508.
  4. Griffin CA, Emanuel BS, Hansen JR, Cavenee WK, Myers JC (Feb 1987). "Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13". Proc Natl Acad Sci U S A. 84 (2): 512–6. doi:10.1073/pnas.84.2.512. PMC 304239Freely accessible. PMID 3025878.
  5. 1 2 "Entrez Gene: COL4A2 collagen, type IV, alpha 2".

Further reading

  • Hinek A (1995). "Nature and the multiple functions of the 67-kD elastin-/laminin binding protein.". Cell Adhes. Commun. 2 (3): 185–93. doi:10.3109/15419069409004436. PMID 7827955. 
  • Ständer M, Naumann U, Wick W, Weller M (1999). "Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth.". Cell Tissue Res. 296 (2): 221–7. doi:10.1007/s004410051283. PMID 10382266. 
  • Kurpakus Wheater M, Kernacki KA, Hazlett LD (1999). "Corneal cell proteins and ocular surface pathology.". Biotechnic & Histochemistry. 74 (3): 146–59. doi:10.3109/10520299909047967. PMID 10416788. 
  • Kalluri R, Sukhatme VP (2000). "Fibrosis and angiogenesis.". Curr. Opin. Nephrol. Hypertens. 9 (4): 413–8. doi:10.1097/00041552-200007000-00013. PMID 10926178. 
  • Ghebrehiwet B, Peerschke EI, Hong Y, et al. (1992). "Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV.". J. Leukoc. Biol. 51 (6): 546–56. PMID 1377218. 
  • Gupta S, Batchu RB, Datta K (1992). "Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface.". Eur. J. Cell Biol. 56 (1): 58–67. PMID 1724753. 
  • Paralkar VM, Nandedkar AK, Pointer RH, et al. (1990). "Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen.". J. Biol. Chem. 265 (28): 17281–4. PMID 2211625. 
  • Hernandez MR, Igoe F, Neufeld AH (1986). "Extracellular matrix of the human optic nerve head.". Am. J. Ophthalmol. 102 (2): 139–48. doi:10.1016/0002-9394(86)90134-0. PMID 2426947. 
  • Siebold B, Deutzmann R, Kühn K (1988). "The arrangement of intra- and intermolecular disulfide bonds in the carboxyterminal, non-collagenous aggregation and cross-linking domain of basement-membrane type IV collagen.". Eur. J. Biochem. 176 (3): 617–24. doi:10.1111/j.1432-1033.1988.tb14321.x. PMID 2844531. 
  • Pöschl E, Pollner R, Kühn K (1988). "The genes for the alpha 1(IV) and alpha 2(IV) chains of human basement membrane collagen type IV are arranged head-to-head and separated by a bidirectional promoter of unique structure.". EMBO J. 7 (9): 2687–95. PMC 457057Freely accessible. PMID 2846280. 
  • Murata K, Motayama T, Kotake C (1986). "Collagen types in various layers of the human aorta and their changes with the atherosclerotic process.". Atherosclerosis. 60 (3): 251–62. doi:10.1016/0021-9150(86)90172-3. PMID 3089234. 
  • Soininen R, Huotari M, Hostikka SL, et al. (1988). "The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region.". J. Biol. Chem. 263 (33): 17217–20. PMID 3182844. 
  • Hostikka SL, Tryggvason K (1989). "The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chain.". J. Biol. Chem. 263 (36): 19488–93. PMID 3198637. 
  • Brazel D, Pollner R, Oberbäumer I, Kühn K (1988). "Human basement membrane collagen (type IV). The amino acid sequence of the alpha 2(IV) chain and its comparison with the alpha 1(IV) chain reveals deletions in the alpha 1(IV) chain.". Eur. J. Biochem. 172 (1): 35–42. doi:10.1111/j.1432-1033.1988.tb13852.x. PMID 3345760. 
  • Hostikka SL, Kurkinen M, Tryggvason K (1987). "Nucleotide sequence coding for the human type IV collagen alpha 2 chain cDNA reveals extensive homology with the NC-1 domain of alpha 1 (IV) but not with the collagenous domain or 3'-untranslated region.". FEBS Lett. 216 (2): 281–6. doi:10.1016/0014-5793(87)80706-8. PMID 3582677. 
  • Killen PD, Francomano CA, Yamada Y, et al. (1988). "Partial structure of the human alpha 2(IV) collagen chain and chromosomal localization of the gene (COL4A2).". Hum. Genet. 77 (4): 318–24. doi:10.1007/BF00291418. PMID 3692475. 
  • Glant TT, Hadházy C, Mikecz K, Sipos A (1985). "Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II.". Histochemistry. 82 (2): 149–58. doi:10.1007/bf00708199. PMID 3997552. 
  • Uscanga L, Kennedy RH, Stocker S, et al. (1984). "Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas.". Digestion. 30 (3): 158–64. doi:10.1159/000199100. PMID 6389236. 

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