CCNL2

CCNL2

Identifiers

CCNL2, ANIA-6B, CCNM, CCNS, HCLA-ISO, HLA-ISO, PCEE, SB138, cyclin L2

External IDs

MGI: 1927119 HomoloGene: 69477 GeneCards: CCNL2

Gene ontology
Molecular function	• cyclin-dependent protein serine/threonine kinase regulator activity • protein kinase binding • protein binding
Cellular component	• nucleus • cyclin-dependent protein kinase holoenzyme complex • intracellular membrane-bounded organelle • nuclear speck • nucleoplasm
Biological process	• regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of phosphorylation of RNA polymerase II C-terminal domain • regulation of cyclin-dependent protein serine/threonine kinase activity • positive regulation of cyclin-dependent protein serine/threonine kinase activity • transcription, DNA-templated
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


81669


56036


ENSG00000221978


ENSMUSG00000029068


Q96S94


Q9JJA7

RefSeq (mRNA)

NM_001039577 NM_001144867 NM_001144868 NM_030937 NM_001320153
NM_001320155


NM_018856 NM_207678

RefSeq (protein)


NP_001034666.1 NP_112199.2 NP_001307082.1 NP_001307084.1


NP_997561.1

Location (UCSC)

Chr 1: 1.39 – 1.4 Mb

Chr 4: 155.81 – 155.82 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Cyclin-L2 is a protein that in humans is encoded by the CCNL2 gene.^[3]

References

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Cheng H, Bjerknes M (1996). "Patterns of gene expression along the crypt-villus axis in mouse jejunal epithelium". Anat. Rec. 244 (1): 78–94. doi:10.1002/(SICI)1097-0185(199601)244:1<78::AID-AR8>3.0.CO;2-B. PMID 8838426.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
de Graaf K, Hekerman P, Spelten O, et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. doi:10.1074/jbc.M310794200. PMID 14623875.
Yang L, Li N, Wang C, et al. (2004). "Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells". J. Biol. Chem. 279 (12): 11639–48. doi:10.1074/jbc.M312895200. PMID 14684736.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

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