CARD11

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4JUP, 4LWD

Identifiers

Aliases

CARD11, BENTA, BIMP3, CARMA1, IMD11, PPBL, caspase recruitment domain family member 11

External IDs

MGI: 1916978 HomoloGene: 13024 GeneCards: CARD11

Gene ontology
Molecular function	• guanylate kinase activity • protein binding • CARD domain binding
Cellular component	• cytoplasm • cytosol • membrane • plasma membrane • T cell receptor complex • immunological synapse • membrane raft • extracellular exosome
Biological process	• regulation of apoptotic process • positive regulation of cytokine production • T cell costimulation • stimulatory C-type lectin receptor signaling pathway • positive regulation of interleukin-2 biosynthetic process • Fc-epsilon receptor signaling pathway • positive regulation of T cell activation • positive regulation of B cell proliferation • positive regulation of T cell proliferation • regulation of immune response • positive regulation of I-kappaB kinase/NF-kappaB signaling • T cell receptor signaling pathway • regulation of B cell differentiation • thymic T cell selection • regulation of T cell differentiation • signal transduction • GMP metabolic process • positive regulation of NF-kappaB transcription factor activity • GDP metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


84433


108723

Ensembl


ENSG00000198286


ENSMUSG00000036526

UniProt


Q9BXL7


Q8CIS0

RefSeq (mRNA)


NM_032415 NM_001324281


NM_175362

RefSeq (protein)


NP_115791.3 NP_001311210.1


NP_780571.2

Location (UCSC)

Chr 7: 2.91 – 3.04 Mb

Chr 5: 140.87 – 141 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Caspase recruitment domain-containing protein 11 also known as CARD-containing MAGUK protein 1 (Carma 1) is a protein that in humans is encoded by the CARD11 gene.^[3]^[4]^[5]

Function

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κB activation. When expressed in cells, this protein activates NF-kappaB and induces the phosphorylation of BCL10.^[5]

Interactions

CARD11 has been shown to interact with BCL10.^[6]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (Apr 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692.
↑ Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2-3): 121–7. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195.
1 2 "Entrez Gene: CARD11 caspase recruitment domain family, member 11".
↑ Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (April 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692.

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Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.
Wang D, You Y, Case SM, McAllister-Lucas LM, Wang L, DiStefano PS, Nuñez G, Bertin J, Lin X (2002). "A requirement for CARMA1 in TCR-induced NF-kappa B activation". Nat. Immunol. 3 (9): 830–5. doi:10.1038/ni824. PMID 12154356.
Gaide O, Favier B, Legler DF, Bonnet D, Brissoni B, Valitutti S, Bron C, Tschopp J, Thome M (2002). "CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation". Nat. Immunol. 3 (9): 836–43. doi:10.1038/ni830. PMID 12154360.
Pomerantz JL, Denny EM, Baltimore D (2002). "CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex". EMBO J. 21 (19): 5184–94. doi:10.1093/emboj/cdf505. PMC 129028. PMID 12356734.
Wang D, Matsumoto R, You Y, Che T, Lin XY, Gaffen SL, Lin X (2004). "CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1". Mol. Cell. Biol. 24 (1): 164–71. doi:10.1128/MCB.24.1.164-171.2003. PMC 303359. PMID 14673152.
Stilo R, Liguoro D, Di Jeso B, Formisano S, Consiglio E, Leonardi A, Vito P (2004). "Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator". J. Biol. Chem. 279 (33): 34323–31. doi:10.1074/jbc.M402244200. PMID 15184390.
Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S (2005). "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation". Science. 308 (5718): 114–8. doi:10.1126/science.1107107. PMID 15802604.
Shinohara H, Yasuda T, Aiba Y, Sanjo H, Hamadate M, Watarai H, Sakurai H, Kurosaki T (2005). "PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1". J. Exp. Med. 202 (10): 1423–31. doi:10.1084/jem.20051591. PMC 2212994. PMID 16301747.
Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, Rawlings DJ (2005). "Phosphorylation of the CARMA1 linker controls NF-kappaB activation". Immunity. 23 (6): 561–74. doi:10.1016/j.immuni.2005.09.014. PMID 16356855.
Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B, Chen Y, Wang D, Lin X (2005). "Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation". Immunity. 23 (6): 575–85. doi:10.1016/j.immuni.2005.10.007. PMID 16356856.
Narayan P, Holt B, Tosti R, Kane LP (2006). "CARMA1 is required for Akt-mediated NF-kappaB activation in T cells". Mol. Cell. Biol. 26 (6): 2327–36. doi:10.1128/MCB.26.6.2327-2336.2006. PMC 1430296. PMID 16508008.
Ishiguro K, Avruch J, Landry A, Qin S, Ando T, Goto H, Xavier R (2006). "Nore1B regulates TCR signaling via Ras and Carma1". Cell. Signal. 18 (10): 1647–54. doi:10.1016/j.cellsig.2006.01.015. PMC 3204664. PMID 16520020.
Ishiguro K, Green T, Rapley J, Wachtel H, Giallourakis C, Landry A, Cao Z, Lu N, Takafumi A, Goto H, Daly MJ, Xavier RJ (2006). "Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation". Mol. Cell. Biol. 26 (14): 5497–508. doi:10.1128/MCB.02469-05. PMC 1592706. PMID 16809782.

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CARD11

Function

Interactions

References

Further reading