C14orf159

C14orf159
Identifiers
Aliases	C14orf159
External IDs	MGI: 2444813 HomoloGene: 11798 GeneCards: C14orf159
Gene ontology Molecular function • molecular function • protein binding Cellular component • mitochondrion • cellular component Biological process • biological process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	80017	217830
Ensembl	ENSG00000133943	ENSMUSG00000021185
UniProt	Q7Z3D6	Q8BH86
RefSeq (mRNA)	NM_024952 NM_001102366 NM_001102367 NM_001102368 NM_001102369 NM_001286470 NM_001286471 NM_001286472 NM_001286473	NM_145448
RefSeq (protein)	NP_001095836.1 NP_001095837.1 NP_001095838.1 NP_001095839.1 NP_001273399.1 NP_001273400.1 NP_001273401.1 NP_001273402.1 NP_079228.4	NP_663423.2
Location (UCSC)	Chr 14: 91.06 – 91.23 Mb	Chr 12: 100.78 – 100.9 Mb
PubMed search	[1]	[2]
Wikidata

UPF0317 protein C14orf159, mitochondrial is a protein that in humans is encoded by the C14orf159 gene (chromosome 14 open reading frame 159).^[3]

Orthologs

The human gene, c14orf159 mRNA, is highly conserved in mammals and birds.^[4] Orthologs gathered from BLAST and BLAT searches reveal that the human c14orf159 mRNA sequence is conserved with a sequence identity of 98% in chimpanzees, 88% in mice, and 81% in platypus and chicken.^[5][6] The following table contains a list orthologs that were gathered from BLAST searches. Sequence alignments were performed using blastn to derive sequence identity, score, and E-values between the human c14orf159 variant 1 mRNA and its orthologs.

The protein that the human gene c14orf159 encodes has been found to be highly conserved among mammals, birds, amphibians, fish, tunicates, cnidarians, and echinoderms. However, no protein orthologs have been found in nematodes, arthropods, fungi, protists, plants, bacteria, or archea. Fungi and bacteria contain the DUF1445 conserved domain which is found in human c14orf159 and its orthologs. BLAST and BLAT searches have been utilized to find orthologs to the c14orf159 protein. The following table lists protein orthologs for the human protein with sequence identity, sequence similarity, scores, and E-values derived from blastp sequence comparisons.^[7]

Post-translational modification

The protein product of the C14orf159 gene is predicted^[3] and was found^[8][9] to be translocated to mitochondrion.

Post-translational modifications are predicted for the protein c14orf159. All predicted sites in human c14orf159 were compared to orthologs using multiple sequence alignments to determine likelihood of modification.^{[10][11][12][13] [14]}

Regulation

Estrogen receptor alpha, in the presence of estradiol, binds to the C14orf159 gene and likely regulates its expression.^[15]

References

Further reading