Brendan Murphy may refer to:
- Brendan Murphy (Carlow footballer) (born 1989), and former international rules and Australian rules player
- Brendan Murphy (Meath footballer) (born 1975), also a former professional soccer player with Bradford City A.F.C., Wimbledon F.C., Kidderminster Harriers F.C., Dundalk F.C. and Longford Town F.C.
- Brendan Murphy (hurler) (born 1980), Offaly GAA hurler