Beclamide

Beclamide

Clinical data
Routes of administration	By mouth
ATC code	N03AX30 (WHO)
Identifiers
IUPAC name N-Benzyl-3-chloropropanamide
CAS Number	501-68-8 Y
PubChem (CID)	10391
ChemSpider	9962 Y
UNII	F5N0ALI65V Y
KEGG	D07300 Y
ChEMBL	CHEMBL64195 Y
Chemical and physical data
Formula	C10H12ClNO
Molar mass	197.661 g/mol
3D model (Jmol)	Interactive image
SMILES ClCCC(=O)NCc1ccccc1
InChI InChI=1S/C10H12ClNO/c11-7-6-10(13)12-8-9-4-2-1-3-5-9/h1-5H,6-8H2,(H,12,13) Y Key:JPYQFYIEOUVJDU-UHFFFAOYSA-N Y
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Beclamide (marketed as Chloracon, Hibicon, Posedrine, Nydrane, Seclar, and other names) is a drug that possesses anticonvulsant activity.^[1] It is no longer used.

Uses

It has been used as a sedative and as an anticonvulsant.

It was studied in the 1950s for its anticonvulsant properties, as a treatment for generalised tonic-clonic seizures. It was not effective for absence seizures.

Interest in the drug resumed in the 1990s for its psychiatric properties as an adjunct in the treatment of schizophrenia.^[2]

Side effects

Side effects are uncommon but include stomach pain, nervousness, giddiness, skin rash and leukopenia. It is counter-indicated in breast feeding as it is passed in the milk.

Administration and pharmacology

Administration is oral, though it has an unpleasant taste. It is quickly absorbed and elimination is renal and complete within 48 hours. Beclamide is possibly metabolized to 3-chloropropanoic acid in vivo, which binds to the GHB receptor.

References

• The Medical Treatment of Epilepsy by Stanley R Resor. Published by Marcel Dekker (1991). ISBN 0-8247-8549-5.