Arachidonylcyclopropylamide

Arachidonylcyclopropylamide
Names
IUPAC name
N-(Cyclopropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Other names
ACPA
Identifiers
229021-64-1 N
3D model (Jmol) Interactive image
ChEMBL ChEMBL418353 YesY
ChemSpider 4470548 YesY
739
PubChem 5311007
Properties
C23H37NO
Molar mass 343.56 g·mol−1
Solubility in other solvents soluble in ethanol, chloroform, THF and DMSO
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N (what is YesYN ?)
Infobox references

Arachidonylcyclopropylamide (ACPA) is a synthetic agonist of the cannabinoid receptor 1 (CB1R). ACPA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R) (Ki = 2.2 nM for CB1R; Ki = 700 nM for CB2R).[1]

References

  1. Hillard, CJ; et al. (1999). "Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)". The Journal of Pharmacology and Experimental Therapeutics. 289 (3): 1427–33. PMID 10336536.
This article is issued from Wikipedia - version of the 7/7/2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.