Anne Dejean-Assémat
| Anne Dejean-Assémat | |
|---|---|
 | |
| Born |
6 January 1957 Cholet, France |
| Education | University of Paris 6 |
| Awards | Member of the French Academy of Sciences |
| Website | https://research.pasteur.fr/en/team/nuclear-organization-and-oncogenesis/ |
Anne Dejean-Assémat (born 6 January 1957) is Director of Research INSERM and Professor at the Institut Pasteur.[1] She heads the Laboratory of Nuclear Organization and Oncogenesis[2] at the Institut Pasteur and the INSERM Unit 993. She was elected member of the French Academy of Science in 2004.
Education
Anne Dejean-Assémat was educated at the Pierre et Marie Curie University in Paris, graduating with a Master of Science degree in Genetics in 1981. She then earned her PhD from the University Pierre et Marie Curie at the Institut Pasteur in 1988 under the supervision of Piotr Slonimski.
Science
A molecular biologist, Anne Dejean-Assémat investigates the molecular and cellular mechanisms involved in the development of human cancers.
She discovered the role of mutations in retinoic acid receptors in liver cancer and acute promyelocytic leukaemia and dissected the molecular mechanisms underlying their role in oncogenesis and treatment sensitivity. Anne Dejean-Assémat and her collaborators have made important advances in understanding the origin of certain cancers and have opened up unique perspectives for new targeted therapeutic leads. Her main contributions are :
- First demonstration of a direct role for the Hepatitis B Virus in human liver cancer as an insertional mutagen
- Discovery of the first retinoic acid receptor gene at an HBV integration site
- Cloning of the first retinoic acid responsive element
- Molecular cloning of the PML-RAR oncoprotein responsible for Acute Promyelocytic Leukemia (APL)
- Discovery of a novel nuclear organelle, the PML Nuclear Body, involved in human leukemogenesis
- Establishment of the molecular basis for the therapeutic effect of retinoic acid in APL
- Discovery of the molecular basis for the therapeutic role of arsenic in APL : PML-RAR polysumoylation and degradation
- Establishment of the first mouse model for hyposumoylation
Society Membership
- EMBO Member, 1995
- Corresponding Member of the French Academy of Medicine, 2004
- Member of the French Academy of Science,[3] 2004
- Member of the Academia Europea, 2005
- Member of the European Academy of Sciences, 2011
Awards and Honors
- Prize Medical Research Foundation, 1989
- Prize Bernard Halpern, 1991
- Prize André Lwoff, 1994
- Prize Jeanne Loubaresse, Curie Institute, 1996
- Prize Mergier-Bourdeix of the National Academy of Science, 1997
- Prize Rosen, Medical Research Foundation, 1998
- Prize Mitjaville of the National Academy of Medicine, 1999
- Prize Hamdam of Medecine, 2000
- Prize Charles Oberling, 2002
- Prize Gagna and Van Heck, 2003
- Chevalier dans l’ordre national de la Légion d’honneur, 2007
- Officier dans l’ordre national du Mérite, 2012
- Prize Léopold Griffuel, ARC, 2010
- L'Oréal-UNESCO Awards for Women in Science,[4] 2010
- Prize Duquesne, 2014
- Grand Prix INSERM,[5] 2014
References
- ↑ Institut Pasteur. "Members of Institut Pasteur". research.pasteur.fr/. Retrieved 2016-01-31.
- ↑ Institut Pasteur. "Nuclear Organization and Oncogenesis". research.pasteur.fr/. Retrieved 2016-01-31.
- ↑ "Anne Dejean-Assémat | Liste des membres de l'Académie des sciences". www.academie-sciences.fr. Retrieved 2016-01-31.
- ↑ "L'OREAL-UNESCO Awards and Fellowships for Women in Science 2010 to be presented at UNESCO". Unesco.org. Retrieved 2016-01-31.
- ↑ Inserm. "Anne Dejean-Assémat, lauréate du Grand Prix Inserm 2014". www.inserm.fr. Retrieved 2016-01-31.