Acute biphenotypic leukaemia

Acute biphenotypic leukemia
Classification and external resources
ICD-O	9805/3
MeSH	D015456

Acute biphenotypic leukaemia is a form of leukaemia where the lineage is of both lymphoid and myeloid origin.^[1]^[2]

It is a subtype of "leukemia of ambiguous lineage".^[3]

References

↑ Matutes E, Morilla R, Farahat N, et al. (1997). "Definition of acute biphenotypic leukemia". Haematologica. 82 (1): 64–6. PMID 9107085.
↑ Han X, Bueso-Ramos CE (April 2007). "Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias". Am. J. Clin. Pathol. 127 (4): 528–44. doi:10.1309/2QE3A6EKQ8UYDYRC. PMID 17369128.
↑ Frater JL, Yaseen NR, Peterson LC, Tallman MS, Goolsby CL (March 2003). "Biphenotypic acute leukemia with coexpression of CD79a and markers of myeloid lineage". Arch. Pathol. Lab. Med. 127 (3): 356–9. doi:10.1043/0003-9985(2003)127<0356:BALWCO>2.0.CO;2. PMID 12653584.

Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)

B cell
(lymphoma,
leukemia)
(most CD19

CD20)

By
development/
marker

TdT+	ALL (Precursor B acute lymphoblastic leukemia/lymphoma)

CD5+	naive B cell (CLL/SLL) mantle zone (Mantle cell)

CD22+	Prolymphocytic CD11c+ (Hairy cell leukemia)

CD79a+	germinal center/follicular B cell (Follicular Burkitt's GCB DLBCL Primary cutaneous follicle center lymphoma) marginal zone/marginal zone B-cell (Splenic marginal zone MALT Nodal marginal zone Primary cutaneous marginal zone lymphoma)

RS (CD15+, CD30+)	Classic Hodgkin's lymphoma (Nodular sclerosis) CD20+ (Nodular lymphocyte predominant Hodgkin's lymphoma)

PCDs/PP (CD38+/CD138+)	see immunoproliferative immunoglobulin disorders

By infection

KSHV (Primary effusion)
EBV (Lymphomatoid granulomatosis
Post-transplant lymphoproliferative disorder)
HIV (AIDS-related lymphoma)
Helicobacter pylori (MALT lymphoma)

Cutaneous

T/NK

T cell
(lymphoma,
leukemia)
(most CD3

CD4
CD8)

By
development/
marker

TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)

prolymphocyte (Prolymphocytic)

Cutaneous

MF+variants	indolent: Mycosis fungoides Pagetoid reticulosis Granulomatous slack skin aggressive: Sézary disease Adult T-cell leukemia/lymphoma

Non-MF	CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma Pleomorphic T-cell lymphoma Lymphomatoid papulosis type B CD30+: CD30+ cutaneous T-cell lymphoma Secondary cutaneous CD30+ large-cell lymphoma Lymphomatoid papulosis type A

Other
peripheral

By infection

HTLV-1 (Adult T-cell leukemia/lymphoma)

NK cell/
(most CD56)

T or NK

Lymphoid+
myeloid

Acute biphenotypic leukaemia

Lymphocytosis

Cutaneous lymphoid hyperplasia

Myeloid hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)

CFU-GM/
and other granulocytes

CFU-GM

Myelocyte

AML:	Acute myeloblastic leukemia M0 M1 M2 APL/M3

MP	Chronic neutrophilic leukemia

Monocyte

AML	AMoL/M5 Myeloid dendritic cell leukemia

CML	Philadelphia chromosome Accelerated phase chronic myelogenous leukemia

Myelomonocyte

AML	M4

MD-MP	Juvenile myelomonocytic leukemia Chronic myelomonocytic leukemia

Other

Histiocytosis

CFU-Baso

AML	Acute basophilic

CFU-Eos

AML	Acute eosinophilic

MP	Chronic eosinophilic leukemia/Hypereosinophilic syndrome

MEP

CFU-Meg

AML	AMKL/M7

MP	Essential thrombocytosis

CFU-E

AML	Erythroleukemia/M6

MP	Polycythemia vera

MD	Refractory anemia Refractory anemia with excess of blasts Chromosome 5q deletion syndrome Sideroblastic anemia Paroxysmal nocturnal hemoglobinuria Refractory cytopenia with multilineage dysplasia

CFU-Mast

Mastocytoma	Mast cell leukemia Mast cell sarcoma Systemic mastocytosis

Mastocytosis:	Diffuse cutaneous mastocytosis Erythrodermic mastocytosis Adult type of generalized eruption of cutaneous mastocytosis Urticaria pigmentosa Mast cell sarcoma Solitary mastocytoma

Systemic mastocytosis	Xanthelasmoidal mastocytosis

Multiple/unknown

AML	Acute panmyelosis with myelofibrosis Myeloid sarcoma

MP	Myelofibrosis Acute biphenotypic leukaemia

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