ATP6V0A4

ATP6V0A4
Identifiers
Aliases	ATP6V0A4, A4, ATP6N1B, ATP6N2, RDRTA2, RTA1C, RTADR, STV1, VPH1, VPP2, ATPase H+ transporting V0 subunit a4
External IDs	MGI: 2153480 HomoloGene: 39904 GeneCards: ATP6V0A4
Gene ontology Molecular function • ATPase binding • proton-transporting ATPase activity, rotational mechanism • protein binding • hydrogen ion transmembrane transporter activity Cellular component • integral component of membrane • endosome • proton-transporting V-type ATPase, V0 domain • phagocytic vesicle membrane • membrane • vacuolar proton-transporting V-type ATPase, V0 domain • plasma membrane • apical part of cell • brush border membrane • lysosomal membrane • apical plasma membrane • brush border • vacuolar proton-transporting V-type ATPase complex • endosome membrane • extracellular exosome Biological process • insulin receptor signaling pathway • excretion • transferrin transport • ossification • vacuolar proton-transporting V-type ATPase complex assembly • ion transport • sensory perception of sound • proton transport • vacuolar acidification • ion transmembrane transport • transport • ATP synthesis coupled proton transport • ATP hydrolysis coupled proton transport • regulation of pH • phagosome acidification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50617	140494
Ensembl	ENSG00000105929	ENSMUSG00000038600
UniProt	Q9HBG4	Q920R6
RefSeq (mRNA)	NM_020632 NM_130840 NM_130841	NM_080467
RefSeq (protein)	NP_065683.2 NP_570855.2 NP_570856.2	NP_536715.3
Location (UCSC)	Chr 7: 138.71 – 138.8 Mb	Chr 6: 38.05 – 38.12 Mb
PubMed search	[1]	[2]
Wikidata

V-type proton ATPase 116 kDa subunit a isoform 4 is an enzyme that in humans is encoded by the ATP6V0A4 gene.^[3][4][5]

Function

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.^[5]

Interactions

ATP6V0A4 has been shown to interact with PFKM.^[6]

References

Further reading