ATPase, H+ transporting, lysosomal V0 subunit a1

ATP6V0A1
Identifiers
Aliases	ATP6V0A1, Atp6v0a1, AA959968, ATP6a1, Atp6n1, Atp6n1a, Atpv0a1, Vpp-1, Vpp1, Stv1, Vph1, a1, ATPase, H+ transporting, lysosomal V0 subunit a1, ATP6N1, ATP6N1A, VPP1, ATPase H+ transporting V0 subunit a1
External IDs	MGI: 103286 HomoloGene: 3795 GeneCards: ATP6V0A1
Gene ontology Molecular function • ATPase binding • proton-transporting ATPase activity, rotational mechanism • protein binding • hydrogen ion transmembrane transporter activity Cellular component • cytoplasm • integral component of membrane • proton-transporting V-type ATPase, V0 domain • phagocytic vesicle membrane • Golgi apparatus • cell • intracellular membrane-bounded organelle • membrane • vacuolar proton-transporting V-type ATPase, V0 domain • melanosome • plasma membrane • nucleoplasm • vacuolar proton-transporting V-type ATPase complex • endosome membrane • extracellular exosome • cytoplasmic vesicle membrane • cytoplasmic vesicle Biological process • insulin receptor signaling pathway • transferrin transport • vacuolar proton-transporting V-type ATPase complex assembly • toxin transport • ion transport • proton transport • ion transmembrane transport • transport • ATP synthesis coupled proton transport • ATP hydrolysis coupled proton transport • regulation of macroautophagy • vacuolar acidification • phagosome acidification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	535	11975
Ensembl	ENSG00000033627	ENSMUSG00000019302
UniProt	Q93050	Q9Z1G4
RefSeq (mRNA)	NM_001130020 NM_001130021 NM_005177	NM_001243049 NM_001243050 NM_001243051 NM_016920
RefSeq (protein)	NP_001123492.1 NP_001123493.1 NP_005168.2	NP_001229979.1 NP_001229980.1 NP_058616.1
Location (UCSC)	Chr 17: 42.46 – 42.52 Mb	Chr 11: 101.01 – 101.06 Mb
PubMed search	[1]	[2]
Wikidata

V-type proton ATPase 116 kDa subunit a isoform 1 is an enzyme that in humans is encoded by the ATP6V0A1 gene.^[3][4]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. The occurrence of splice variants encoding different protein products has been reported, but the full-length natures of these transcripts have not been determined.^[4]

References

Further reading