ATP1B1

Identifiers

ATP1B1, ATP1B, ATPase Na+/K+ transporting subunit beta 1

External IDs

MGI: 88108 HomoloGene: 37509 GeneCards: ATP1B1

Gene ontology
Molecular function	• ATPase binding • potassium ion binding • sodium ion binding • sodium:potassium-exchanging ATPase activity • ATPase activity • protein C-terminus binding • protein binding • MHC class II protein complex binding • drug binding • ATPase activator activity • ATP binding
Cellular component	• extracellular vesicle • integral component of membrane • membrane • intercalated disc • myelin sheath • plasma membrane • intracellular • sodium:potassium-exchanging ATPase complex • basolateral plasma membrane • apical plasma membrane • caveola • sarcolemma • extracellular exosome
Biological process	• regulation of cardiac conduction • regulation of cardiac muscle contraction by calcium ion signaling • response to hypoxia • positive regulation of ATPase activity • cardiac muscle contraction • positive regulation of sodium ion export from cell • sodium ion transport • cellular sodium ion homeostasis • sodium ion export from cell • metal ion transport • cell communication by electrical coupling involved in cardiac conduction • protein stabilization • positive regulation of potassium ion import • cellular calcium ion homeostasis • ion transport • cellular potassium ion homeostasis • potassium ion transport • membrane repolarization • ion transmembrane transport • ATP metabolic process • cell adhesion • potassium ion import • transport • regulation of gene expression • positive regulation of calcium:sodium antiporter activity • protein localization to plasma membrane • membrane repolarization during cardiac muscle cell action potential • relaxation of cardiac muscle • regulation of calcium ion transmembrane transport • leukocyte migration • xenophagy • positive regulation of potassium ion transmembrane transporter activity • protein transport into plasma membrane raft • positive regulation of defense response to virus by host • potassium ion import across plasma membrane • ATP hydrolysis coupled transmembrane transport • establishment or maintenance of transmembrane electrochemical gradient
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


481


11931

Ensembl


ENSG00000143153


ENSMUSG00000026576

UniProt


P05026


P14094

RefSeq (mRNA)


NM_001677 NM_001001787


NM_009721

RefSeq (protein)


NP_001668.1


NP_033851.1

Location (UCSC)

Chr 1: 169.11 – 169.13 Mb

Chr 1: 164.44 – 164.46 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Sodium/potassium-transporting ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene.^[3]

The protein encoded by this gene belongs to the family of Na⁺/K⁺ and H⁺/K⁺ ATPases beta chain proteins, and to the subfamily of Na⁺/K⁺-ATPases. Na⁺/K⁺-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na⁺/K⁺-ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.^[3]

References

Lingrel JB, Orlowski J, Shull MM, Price EM (1990). "Molecular genetics of Na,K-ATPase". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 38: 37–89. doi:10.1016/S0079-6603(08)60708-4. ISBN 978-0-12-540038-1. PMID 2158121.
Oakey RJ, Watson ML, Seldin MF (1993). "Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA". Hum. Mol. Genet. 1 (8): 613–20. doi:10.1093/hmg/1.8.613. PMID 1301170.
Martin-Vasallo P, Dackowski W, Emanuel JR, Levenson R (1989). "Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression". J. Biol. Chem. 264 (8): 4613–8. PMID 2538450.
Ushkaryov YuA, Monastyrskaya GS, Broude NE, et al. (1990). "Human Na⁺,K⁺-ATPase genes. Beta-subunit gene family contains at least one gene and one pseudogene". FEBS Lett. 257 (2): 439–42. doi:10.1016/0014-5793(89)81591-1. PMID 2555225.
Lane LK, Shull MM, Whitmer KR, Lingrel JB (1990). "Characterization of two genes for the human Na,K-ATPase beta subunit". Genomics. 5 (3): 445–53. doi:10.1016/0888-7543(89)90008-6. PMID 2559024.
Yang-Feng TL, Schneider JW, Lindgren V, et al. (1988). "Chromosomal localization of human Na⁺, K⁺-ATPase alpha- and beta-subunit genes". Genomics. 2 (2): 128–38. doi:10.1016/0888-7543(88)90094-8. PMID 2842249.
Sverdlov ED, Broude NE, Sverdlov VE, et al. (1987). "Family of Na⁺,K⁺-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism". FEBS Lett. 221 (1): 129–33. doi:10.1016/0014-5793(87)80366-6. PMID 2887455.
Kawakami K, Nojima H, Ohta T, Nagano K (1986). "Molecular cloning and sequence analysis of human Na,K-ATPase beta-subunit". Nucleic Acids Res. 14 (7): 2833–44. doi:10.1093/nar/14.7.2833. PMC 339706. PMID 3008098.
Coca-Prados M, Fernández-Cabezudo MJ, Sánchez-Torres J, et al. (1996). "Cell-specific expression of the human Na⁺,K⁺-ATPase beta 2 subunit isoform in the nonpigmented ciliary epithelium". Invest. Ophthalmol. Vis. Sci. 36 (13): 2717–28. PMID 7499094.
Ruiz A, Bhat SP, Bok D (1995). "Characterization and quantification of full-length and truncated Na,K-ATPase alpha 1 and beta 1 RNA transcripts expressed in human retinal pigment epithelium". Gene. 155 (2): 179–84. doi:10.1016/0378-1119(94)00812-7. PMID 7536695.
Mobasheri A, Oukrif D, Dawodu SP, et al. (2001). "Isoforms of Na⁺, K⁺-ATPase in human prostate; specificity of expression and apical membrane polarization". Histol. Histopathol. 16 (1): 141–54. PMID 11193188.
Gamaleĭ IA, Polozov IuS, Aksenov ND, et al. (2001). "[Cell cycle and formation of active form of oxygen in rodent fibroblasts]". Tsitologiia. 43 (6): 602–12. PMID 11534180.
Béguin P, Crambert G, Monnet-Tschudi F, et al. (2002). "FXYD7 is a brain-specific regulator of Na,K-ATPase α1–β isozymes". EMBO J. 21 (13): 3264–73. doi:10.1093/emboj/cdf330. PMC 125393. PMID 12093728.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
Fuller W, Eaton P, Bell JR, Shattock MJ (2004). "Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase". FASEB J. 18 (1): 197–9. doi:10.1096/fj.03-0213fje. PMID 14597563.
Li J, Codina J, Petroske E, et al. (2004). "The carboxy terminus of the colonic H⁺, K⁺-ATPase alpha-subunit is required for stable beta subunit assembly and function". Kidney Int. 65 (4): 1301–10. doi:10.1111/j.1523-1755.2004.00507.x. PMID 15086469.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wickham L, Benjannet S, Marcinkiewicz E, et al. (2005). "Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin". J. Neurochem. 92 (1): 93–102. doi:10.1111/j.1471-4159.2004.02840.x. PMID 15606899.

Hydrolases: acid anhydride hydrolases (EC 3.6)

3.6.1

3.6.2

3.6.3-4: ATPase

3.6.3

Cu++ (3.6.3.4)	Menkes/ATP7A Wilson/ATP7B

Ca+ (3.6.3.8)	SERCA ATP2A1 ATP2A2 ATP2A3 Plasma membrane ATP2B1 ATP2B2 ATP2B3 ATP2B4 SPCA ATP2C1 ATP2C2

Na+/K+ (3.6.3.9)	ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP1B4

H+/K+ (3.6.3.10)	ATP4A

Other P-type ATPase	ATP8B1 ATP10A ATP11B ATP12A ATP13A2 ATP13A3

3.6.4

3.6.5: GTPase

3.6.5.1: Heterotrimeric G protein	G_αs G_αi GNAI1 GNAI2 GNAI3 G_αq/11 GNAQ GNA11 G_α12/13 GNA12 GNA13 Transducin GNAT1 GNAT2 Gustducin GNAT3

3.6.5.2: Small GTPase > Ras superfamily	Rho family of GTPases: Cdc42 CDC42 TC10 TCL RhoUV RhoU RhoV Rac Rac1 2 3 RhoG RhoBTB 1 2 RhoH Rho A B C Rnd 1 2 3 RhoDF RhoF RhoD other: Ras HRAS KRAS NRAS Rab RAB23 RAB27 Arf ARF6 SAR1B ARL13B ARL6 Ran Rheb Rap RGK

3.6.5.3: Protein-synthesizing GTPase	Prokaryotic IF-2 EF-Tu EF-G Eukaryotic

3.6.5.5-6: Polymerization motors	Dynamin Tubulin

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ATP1B1

References

Further reading