ARPC1A

ARPC1A
Identifiers
Aliases	ARPC1A, Arc40, HEL-68, SOP2Hs, SOP2L, HEL-S-307, actin related protein 2/3 complex subunit 1A
External IDs	MGI: 1928896 HomoloGene: 4675 GeneCards: ARPC1A
Gene ontology Molecular function • actin binding • actin filament binding Cellular component • cytoplasm • cytosol • Arp2/3 protein complex • muscle cell projection membrane • extracellular exosome • cytoskeleton • actin cytoskeleton Biological process • ephrin receptor signaling pathway • regulation of actin filament polymerization • actin cytoskeleton organization • Fc-gamma receptor signaling pathway involved in phagocytosis • Arp2/3 complex-mediated actin nucleation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10552	56443
Ensembl	ENSG00000241685	ENSMUSG00000029621
UniProt	Q92747	Q9R0Q6
RefSeq (mRNA)	NM_006409 NM_001190996	NM_019767
RefSeq (protein)	NP_006400.2	NP_062741.1
Location (UCSC)	Chr 7: 99.33 – 99.39 Mb	Chr 5: 145.08 – 145.11 Mb
PubMed search	[1]	[2]
Wikidata

Actin-related protein 2/3 complex subunit 1A is a protein that in humans is encoded by the ARPC1A gene.^[3][4][5]

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages.^[5]

References

Further reading