ARHGAP9

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
2P0D, 2P0H

Identifiers

Aliases

ARHGAP9, 10C, RGL1, Rho GTPase activating protein 9

External IDs

MGI: 2143764 HomoloGene: 13041 GeneCards: ARHGAP9

Gene ontology
Molecular function	• protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • lipid binding • GTPase activator activity
Cellular component	• cytosol
Biological process	• regulation of small GTPase mediated signal transduction • signal transduction • positive regulation of GTPase activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


64333


216445

Ensembl


ENSG00000123329


ENSMUSG00000040345

UniProt


Q9BRR9


n/a

RefSeq (mRNA)

NM_001080156 NM_001080157 NM_032496 NM_001319850 NM_001319851
NM_001319852


NM_001285785 NM_146011

RefSeq (protein)

NP_001073625.1 NP_001073626.1 NP_115885.2 NP_001306779.1 NP_001306780.1
NP_001306781.1 NP_001306779.1


n/a

Location (UCSC)

Chr 12: 57.47 – 57.49 Mb

Chr 10: 127.32 – 127.33 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ARHGAP9 gene.^[3]^[4]

Function

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Furukawa Y, Kawasoe T, Daigo Y, Nishiwaki T, Ishiguro H, Takahashi M, Kitayama J, Nakamura Y (Jun 2001). "Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein". Biochemical and Biophysical Research Communications. 284 (3): 643–9. doi:10.1006/bbrc.2001.5022. PMID 11396949.
1 2 "Entrez Gene: ARHGAP9 Rho GTPase activating protein 9".

Peck J, Douglas G, Wu CH, Burbelo PD (Sep 2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships". FEBS Letters. 528 (1-3): 27–34. doi:10.1016/S0014-5793(02)03331-8. PMID 12297274.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.

PDB gallery

2p0d: ArhGAP9 PH domain in complex with Ins(1,4,5)P3

2p0f: ArhGAP9 PH domain in complex with Ins(1,3,5)P3

2p0h: ArhGAP9 PH domain in complex with Ins(1,3,4)P3

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ARHGAP9

Function

References

Further reading