AMG-36

AMG-36
Identifiers
CAS Number 579444-43-2
PubChem (CID) 10982174
ChemSpider 9157375 YesY
ChEMBL CHEMBL108868 YesY
Chemical and physical data
Formula C27H40O2
Molar mass 396.604 g/mol
3D model (Jmol) Interactive image
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AMG-36 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC substituted with a cyclopentane group on the 3-position side chain. AMG-36 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.45 nM at CB1 vs 1.92 nM at CB2.[1][2]

See also

References

  1. Papahatjis DP, et al. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753
  2. Papahatjis DP, et al. C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols. Journal of Medicinal Chemistry. 2007 Aug 23;50(17):4048-60. PMID 17672444


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