4-aminobutyrate—pyruvate transaminase
| 4-aminobutyrate---pyruvate transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.6.1.96 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
4-aminobutyrate---pyruvate transaminase (EC 2.6.1.96, aminobutyrate aminotransferase, gamma-aminobutyrate aminotransaminase, gamma-aminobutyrate transaminase, gamma-aminobutyric acid aminotransferase, gamma-aminobutyric acid pyruvate transaminase, gamma-aminobutyric acid transaminase, gamma-aminobutyric transaminase, 4-aminobutyrate aminotransferase, 4-aminobutyric acid aminotransferase, aminobutyrate transaminase, GABA aminotransferase, GABA transaminase, GABA transferase, POP2 (gene)) is an enzyme with systematic name 4-aminobutanoate:pyruvate aminotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- (1) 4-aminobutanoate + pyruvate succinate semialdehyde + L-alanine
- (2) 4-aminobutanoate + glyoxylate succinate semialdehyde + glycine
This enzyme requires pyridoxal 5'-phosphate.
References
- ↑ Van Cauwenberghe, O.R.; Shelp, B.J. (1999). "Biochemical characterization of partially purified gaba:pyruvate transaminase from Nicotiana tabacum". Phytochemistry. 52: 575–581. doi:10.1016/s0031-9422(99)00301-5.
- ↑ Palanivelu, R.; Brass, L.; Edlund, A.F.; Preuss, D. (2003). "Pollen tube growth and guidance is regulated by POP2, an Arabidopsis gene that controls GABA levels". Cell. 114 (1): 47–59. doi:10.1016/s0092-8674(03)00479-3. PMID 12859897.
- ↑ Clark, S.M.; Di Leo, R.; Dhanoa, P.K.; Van Cauwenberghe, O.R.; Mullen, R.T.; Shelp, B.J. (2009). "Biochemical characterization, mitochondrial localization, expression, and potential functions for an Arabidopsis γ-aminobutyrate transaminase that utilizes both pyruvate and glyoxylate". J. Exp. Bot. 60: 1743–1757. doi:10.1093/jxb/erp044. PMID 19264755.
- ↑ Clark, S.M.; Di Leo, R.; Van Cauwenberghe, O.R.; Mullen, R.T.; Shelp, B.J. (2009). "Subcellular localization and expression of multiple tomato γ-aminobutyrate transaminases that utilize both pyruvate and glyoxylate". J. Exp. Bot. 60: 3255–3267. doi:10.1093/jxb/erp161. PMID 19470656.
External links
- 4-aminobutyrate---pyruvate transaminase at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia - version of the 5/16/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.