NSUN5

NSUN5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B9E
Identifiers
Aliases	NSUN5, NOL1, NOL1R, NSUN5A, WBSCR20, WBSCR20A, p120, p120(NOL1), NOP2/Sun RNA methyltransferase family member 5
External IDs	MGI: 2140844 HomoloGene: 6828 GeneCards: NSUN5
Gene ontology Molecular function • methyltransferase activity • transferase activity • poly(A) RNA binding • RNA binding • S-adenosylmethionine-dependent methyltransferase activity • RNA methyltransferase activity Cellular component • nucleus • nucleolus Biological process • rRNA processing • methylation • rRNA base methylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55695	100609
Ensembl	ENSG00000130305	ENSMUSG00000000916
UniProt	Q96P11	Q8K4F6
RefSeq (mRNA)	NM_001168347 NM_001168348 NM_018044 NM_148956	NM_145414
RefSeq (protein)	NP_001161819.1 NP_001161820.1 NP_060514.1 NP_683759.1	NP_663389.2
Location (UCSC)	Chr 7: 73.3 – 73.31 Mb	Chr 5: 135.37 – 135.38 Mb
PubMed search	[1]	[2]
Wikidata

Putative methyltransferase NSUN5 is an enzyme that in humans is encoded by the NSUN5 gene.^[3][4][5]

This gene encodes a protein with similarity to p120 (NOL1), a 120-kDa proliferation-associated nucleolar antigen that is a member of an evolutionarily conserved protein family. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene results in two transcript variants encoding different isoforms.^[5]

References

Further reading

PDB gallery
2b9e: Human NSUN5 protein