MRPL23

MRPL23
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL23, L23MRP, RPL23, RPL23L, mitochondrial ribosomal protein L23
External IDs	MGI: 1196612 HomoloGene: 7922 GeneCards: MRPL23
Gene ontology Molecular function • structural constituent of ribosome • nucleotide binding • protein binding • RNA binding Cellular component • mitochondrial inner membrane • ribosome • intracellular ribonucleoprotein complex • intracellular • nucleolus • mitochondrion • mitochondrial large ribosomal subunit Biological process • mitochondrial translational elongation • mitochondrial translational termination • translation • mitochondrial translation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6150	19935
Ensembl	ENSG00000214026	ENSMUSG00000037772
UniProt	Q16540	O35972
RefSeq (mRNA)	NM_021134	NM_011288
RefSeq (protein)	NP_066957.3	NP_035418.1
Location (UCSC)	Chr 11: 1.95 – 1.98 Mb	Chr 7: 142.53 – 142.54 Mb
PubMed search	[1]	[2]
Wikidata

39S ribosomal protein L23, mitochondrial is a protein that in humans is encoded by the MRPL23 gene.^[3][4]

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11.^[4]

References

Further reading