List of experimental and computational labs focusing on IDPs

List of experimental and computational labs focusing on IDPs. In the last ten years, a great number of laboratories have investigated protein disorders using both experimental (e.g. SAXS-NMR, single-molecule fluorescence) and computational (analysis of protein structure) techniques.

• Keith Dunker coined the term IDP, recognised IDPs as distinct class of proteins with important biological functions, established many prediction algorithms to characterise IDPs in thousands of proteomes.^[1][2]
• Peter Tompa contributed early studies of oversized IDPs and disordered plant chaperones.^[3][4]
• Vladimir Uversky is a pioneer in theoretical and experimental biophysics of IDPs.^[5][6]
• Madan Babu is a pioneer in cellular regulation of IDPs and studied how IDP expression and degradation are controlled.^[7][8][9]
• Jim Bardwell is a pioneer in the discovery of intrinsically disordered molecular chaperones.^[10][11]
• Ursula Jakob is a pioneer in conditional disorder and its role for molecular chaperoning.^[12][13]
• Philipp Selenko is a pioneer in in-cell characterisation of IDPs.^[14][15]
• Michael Woodside pioneered optical tweezers studies on aggregation.^[16][17]
• Sir Alan Fersht pioneered structural studies on the most frequently cancer-mutated IDP, p53.^[18][19]
• Stefan Rudiger is a pioneer in Hsp90-associated IDP recognition mechanisms.^[20][21]
• Tobias Madl pioneered SAXS-NMR protein complex determination methodology development.^[22][23]
• Yongli Zhang is a pioneer in IDP unfolding.^[24][25]
• Peter Wright pioneered the mechanistic analysis of coupled folding and binding of IDPs.^[26][27]
• Jane Dyson is a pioneer in NMR studies on various biologically important IDPs.^[28][29]
• Rohit Pappu pioneered modelling of electrostatic malleability of IDP ensembles.^[30][31] and developed powerful modeling tools to predict ensembles of highly charged IDPs based on their charge distributions.^[32]
• Inke Nathke pioneered research on APC, one of the largest IDPs.^[33][34]
• Madelon Maurice is a pioneer in cellular mechanisms of IDP scaffolds in Wnt signalling.^{[35][36][37][38]}
• Richard Kriwacki pioneered structural studies on binding-induced folding of IDPs.^[39][40]
• Benjamin Schuler pioneered single-molecule fluorescence studies on IDPs.^[41][42]
• Ashok Deniz pioneered single-molecule fluorescence studies on IDPs.^[43][44]
• David Klenerman pioneered single-molecule fluorescence studies on IDPs.^[45][46]
• Vincent Hilser extended the theory of allostery and demonstrated that IDPs have an ensemble allosteric advantage.^[47]
• Yosef Shaul pioneered large-scale experimental investigations of IDPs in cells using 20S Proteasome assays.^[48]
• David Eliezer pioneered NMR and ESR studies on IDPs such as alpha-synuclein and tau.^[49][50]

See also

• List of disorder prediction software

References